Browsing Genetics by Title
Now showing items 36-55 of 550
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Bacterial L-forms on tap: an improved methodology to generate Bacillus subtilis L-forms heralds a new era of research
(2012)Bacterial L-forms are cell wall-less forms of bacteria that usually grow with a conventional cell wall. Despite being important for research, L-forms are difficult to generate reproducibly and research in this area is ... -
Bcl-2 family proteins participate in mitochondrial quality control by regulating parkin/PINK1-dependent mitophagy
(2014)Mitophagy facilitates the selective elimination of impaired or depolarized mitochondria through targeting the latter to autophagosomes. Parkin becomes localized to depolarized mitochondria in a PINK1-dependent manner and ... -
Bicaudal is a conserved substrate for Drosophila and mammalian caspases and is essential for cell survival.
(2009)Members of the caspase family of cysteine proteases coordinate cell death through restricted proteolysis of diverse protein substrates and play a conserved role in apoptosis from nematodes to man. However, while numerous ... -
Blood-brain barrier associated tight junction disruption is a hallmark feature of major psychiatric disorders
(2020)Major psychiatric disorders affect 25% of the population. While genetic and environmental risk factors have been identified, the underlying pathophysiology of conditions, such as schizophrenia, bipolar disorder and major ... -
The blood-brain barrier in neuropsychiatric disorders
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Schizophrenia is a severe and disabling mental disorder that affects approximately 1% of the population. Such is the heterogeneous nature of the disease that genetic, neurobiological and environmental factors all contribute ... -
Blood-brain barrier response in the context of sports-related TBI
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2020)Traumatic brain injury (TBI) is one of the largest causes of mortality and disability globally. The severity of TBI is clinically categorised into mild, moderate and severe injuries. Moderate and severe TBI often present ... -
The blood-retina barrier in health and disease
(2021)The blood–retina barrier (BRB) is the term used to define the properties ofthe retinal capillaries and the retinal pigment epithelium (RPE), which sep-arate the systemic circulation from the retina. More specifically, the ... -
Blood-retina barrier regulation and sterile inflammation in retinal homeostasis and disease
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2019)Age-related macular degeneration (AMD) is the leading cause of central vision loss and blindness in the elderly. It is caused by a progressive loss of photoreceptors in the macula, thought to occur secondary to the damage ... -
Boundary cap cells constrain spinal motor neuron somal migration at motor exit points by a semaphorin-plexin mechanism
(2007)Background: In developing neurons, somal migration and initiation of axon outgrowth often occur simultaneously and are regulated in part by similar classes of molecules. When neurons reach their final destinations, however, ... -
Bovini mitochondrial DNA : demographic history and recombination
(Trinity College (Dublin, Ireland). Department of Genetics, 2006)Bovini mitochondrial sequences were analysed at levels from intra-population studies to inter-species analyses. D-loop sequences were analysed to draw conclusions about the domestication of water buffalo and the demographic ... -
Brain barriers virtual: an interim solution or future opportunity?
(2022)Background: Scientific conferences are vital communication events for scientists in academia, industry, and government agencies. In the brain barriers research field, several international conferences exist that allow ... -
CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways.
(2001)Proteins possessing the caspase recruitment domain (CARD) motif have been implicated in pathways leading to activation of caspases or NF-kappaB in the context of apoptosis or inflammation, respectively. Here we report the ... -
Caspase and granzyme regulated events in apoptosis and inflammation
(Trinity College (Dublin, Ireland). Department of Genetics, 2011)The caspase and granzyme proteases are key regulators of both programmed cell death (apoptosis) and inflammation. They achieve this regulation through the limited proteolysis of protein substrates, this has the consequence ... -
Caspase-1 promiscuity is counterbalanced by rapid inactivation of the processed enzyme.
(2011)Members of the caspase family of cysteine proteases coordinate the highly disparate processes of apoptosis and inflammation. However, while hundreds of substrates for the apoptosis effector caspases (caspase-3 and caspase-7) ... -
Caspase-dependent inactivation of proteasome function during programmed cell death in Drosophila and man
(The American Society for Biochemistry and Molecular Biology, 2004)The caspase family of cysteine proteases plays a conserved role in the coordinate demolition of cellular structures during programmed cell death from nematodes to man. Because cells undergoing programmed cell death in ... -
Cell envelope gene expression in phosphate-limited Bacillus subtilis cells.
(2011)The high phosphate content of Bacillus subtilis cell walls dictates that cell wall metabolism is an important feature of the PhoPR-mediated phosphate limitation response. Here we report the expression profiles of ... -
Cell signalling and ADP ribosylation factor 1 (Arf1) effector proteins of African trypanosomes
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)The control of population size and differentiation status is essential for the survival of all organisms. Tight regulation of these processes is of particular importance for parasites. The African trypanosome, Trypanosoma ... -
Changes in alternative splicing of human and mouse genes are accompanied by faster evolution of constitutive exons
(Oxford University Press, 2005)Alternative splicing is known to be an important source of protein sequence variation, but its evolutionary impact has not been explored in detail. Studying alternative splicing requires extensive sampling of the transcriptome, ...