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Synthesis of Tubulin Inhibitors with Variable Molecular Hinges for the Attachment of Aminopeptidase N Targeting Moieties
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)This thesis includes synthesis of various tubulin binding agents and their incorporation in to novel dual acting hybrids, which along with the tubulin inhibition also exhibit aminopeptidase N (APN) inhibition activities. This ... -
Structure and conformation of photosynthetic pigments and related compounds. Conformation analysis of chlorophyll derivatives
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2019)The computational program, Normal-Coordinate Structural Decomposition (NSD), provides meaningful information that allows a comparative analysis about the conformation of tetrapyrroles. Their conformation has an intrinsic ... -
Using NLP Techniques to Enhance Content Discoverability and Reusability for Adaptive Systems
(Trinity College Dublin. School of Computer Science & Statistics. Discipline of Computer Science, 2019)The volume of digital content resources written as text documents is growing every day, at an unprecedented rate. Because this content is generally not structured as easy-to-handle units, it can be very difficult for users ... -
Precision diagnostics of pulsation and evolution in helium-rich low-mass stars
(Trinity College Dublin. School of Physics. Discipline of Physics, 2019)In this thesis we discuss many types of low mass stars linked by their unusually low hydrogen atmospheric abundance, usually completely replaced with helium. We begin with the hot subdwarfs; subdwarf O and B (sdB, sdO) ... -
Carbon Nanomaterials for Improved Performance of Perovskite Solar Cells Processed under High Humidity
(Trinity College Dublin. School of Physics. Discipline of Physics, 2019)The work documented in this thesis concerns optimization of stacks of semiconducting materials for photovoltaic purposes. Hybrid organic-inorganic metal halide perovskite (MHP) is a promising semiconducting material for ...
