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Discovery and engineering of antimicrobial peptides to combat food spoilage
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2019)This work sought to use a bioinformatics based approach to discover plant derived antimicrobial peptides which were structurally similar to human β-defensin 3 (HBD3) and which possessed effective antimicrobial activity ... -
FNR is a regulator of Salmonella pathogenicity Island 2 in Salmonella Typhimurium
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2019)During infection, S. Typhimurium employs Salmonella pathogenicity island (SPI)-encoded type three secretion systems (T3SS) 1 and 2 to invade and survive in host cells. However, expression of SPI-2 is seen at the epithelial ... -
Practical Instructions for the 2018 ESC Guidelines for the diagnosis and management of syncope
(2018)The literature on syncope and associated conditions can be confusing because of a lack of consistency. The meaning of some terms hasbecome obscured, and new terms were introduced to compete witholder, often equally adequate ... -
Should prevention of falls start earlier? Coordinated analyses of harmonised data on falls in middle-aged adults across four population-based cohort studies
(2018)The prevalence of risk factors for falls increases during middle-age, but the prevalence of falls in this age-range is often overlooked and understudied. The aim was to calculate the prevalence of falls in middle-aged ... -
The relationship between kidney function and quality of life among community-dwelling adults varies by age and filtration marker
(2018)Background: The impact of a diminished level of kidney function on the well-being of an older individual is poorly understood. We sought to determine the association between estimated glomerular filtration rate (eGFR) and ...