Browsing Genetics by Title
Now showing items 196-215 of 544
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A GATA/homeodomain transcriptional code regulates axon guidance through the Unc-5 receptor
(2012)Transcription factor codes play an essential role in neuronal specification and axonal guidance in both vertebrate and invertebrate organisms. However, how transcription codes regulate axon pathfinding remains poorly ... -
Gene dosage in the dysbindin schizophrenia susceptibility network differentially affect synaptic function and plasticity
(2015)Neurodevelopmental disorders arise from single or multiple gene defects. However, the way multiple loci interact to modify phenotypic outcomes remains poorly understood. Here, we studied phenotypes associated with mutations ... -
Gene expression changes during retinal development and rod specification
(2015)Purpose: Retinitis pigmentosa (RP) typically results from individual mutations in any one of >70 genes that cause rod photoreceptor cells to degenerate prematurely, eventually resulting in blindness. Gene therapies ... -
Gene expression profiles during early differentiation of mouse embryonic stem cells
(2009)Background Understanding the mechanisms controlling stem cell differentiation is the key to future advances in tissue and organ regeneration. Embryonic stem (ES) cell differentiation can be triggered by embryoid body ... -
Gene order evolution and genomic analyses of the model eukaryote, Saccharomyces cerevisiae, and other yeast species
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2000)The complete genome sequence of the yeast Saccharomyces cerevisiae can be used to form a clearer picture of the evolution of the diverse species of yeast and to construct a model of eukaryote genome evolution. In this study ... -
Gene therapy strategies for dominant heterogeneous disorders and the identification of a novel gene causing retinitis pigmentosa and sensorineural deafness
(Trinity College (Dublin, Ireland). Department of Genetics, 2000)The purpose of this Ph.D. thesis has been to contribute towards the generation of therapies for inherited disorders such as retinitis pigmentosa (RP) and osteogenesis imperfecta (OI). In chapter 2, a novel mitochondrial ... -
Genetic admixture analysis of domesticated cattle
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)Genetic admixture analysis of bovine hybrid zones was carried out through implementation of a variety of statistical and analytical methods. Population genetic analysis of microsatellite variation in seven cattle breeds ... -
Genetic analyses of thalamocortical axon guidance and subpallial development
(Trinity College (Dublin, Ireland). Department of Genetics, 2016)Normal brain functioning in mammals depends on the establishment of specific, finely-organised neural networks connecting distant regions during development. In particular, sensory stimuli processing is supported by ... -
Genetic and expression analysis of cattle identifies candidate genes in pathways responding to Trypanosoma congolense infection.
(2011)African bovine trypanosomiasis caused by Trypanosoma sp., is a major constraint on cattle productivity in sub-Saharan Africa. Some African Bos taurus breeds are highly tolerant of infection, but the potentially more ... -
Genetic diagnosis and treatment of inherited retinopathies
(Trinity College (Dublin, Ireland). Department of Genetics, 2014)The first goal of this PhD was to improve and optimize a gene therapy based on the yeast protein Ndi 1 for Leber's Hereditary Optic Neuropathy (LHON), a mitochondrially-inherited retinal disorder. LHON is an incompletely ... -
Genetic evidence of African slavery at the beginning of the Trans-Atlantic slave trade
(2014)An archaeological excavation in Valle da Gafaria (Lagos, Portugal), revealed two contiguous burial places outside the medieval city walls, dating from the 15th-17th centuries AD: one was interpreted as a Leprosarium cemetery ... -
Genetic heterogeneity in amyotrophic lateral sclerosis and related disorders
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)The overarching aim of this thesis is to clarify and further our understanding of the genetic causes of amyotrophic lateral sclerosis (ALS) and related diseases. It is hoped that achieving this can help bring clarity to ... -
Genetic investigation of Irish ancestry and surname history
(Trinity College (Dublin, Ireland). Department of Genetics, 2005)Several genetic systems were employed in this study to investigate Ireland’s pre-history and history. Initially Irish origins were examined using mtDNA sequence variation in 200 new samples coupled with an extensive novel ... -
Genetic mechanisms establishing thalamocortical connectivity : novel genes and a role for Semaphorin6B
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)One of the main functions of the brain is to process information from the environment. All input to the neocortex passes through the thalamus in order to be handled. Therefore, proper connectivity between the thalamus and ... -
Genetic resistance to Campylobacter jejuni colonization in the chicken
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2011)Campylobacter colonization levels within the chicken gastrointestinal tract vary substantially between individual chickens and this variation in colonization susceptibility can be heritable. In this work the genetic ... -
Genetic structure and trait estimation in ancient Europeans
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)The study of ancient human populations have mostly been carried out, until recently, by historians through the study of written records and ancient manufacts. Thanks to recent technological and theoretical advancements in ... -
Genetic variation in domesticated cattle and wild aurochsen using ancient and modern data
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)A total of 101 Bos taurus teeth and bones aged between 1,000 to 9,000 years old, and 45 B. primigenius primigenius bones aged between 3,720 to 12,380 years old, were assessed for the presence of verifiable mitochondrial ... -
Genetic variation in the bovine genome : signatures of selection and demographic history
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)Domestication, and its associated environmental and demographic changes, undoubtedly brought new challenges to early domesticates, such as cattle. One of the most important would have been the emergence of new disease ...
