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Recent Submissions

  • Therapeutic approaches to halting photoreceptor cell death in the retina 

    Tuohy, Gearóid Patrick (Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2001)
    Retinitis pigmentosa (RP) is a group of hereditary retinopathies affecting approximately 1 in 3500 people in the developed world. The disorders are characterised by the early onset of night blindness followed by a progressive ...
  • Comparative analysis of human and mouse acute phase Serum Amyloid A gene expresseion 

    Thorn, Caroline F. (Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2001)
    The Serum Amyloid A (S AA) proteins are a family of highly conserved lipoproteins secreted by the liver. Their production and release is massively induced under conditions of inflammation or infection by pro-inflammatory ...
  • Novel therapeutic strategies for autosomal dominant retinitis pigmentosa 

    O'Neill, Brian G. D. (Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2000)
    A major difficulty associated with the design of gene therapies for autosomal dominant diseases is the immense intragenic heterogeneity often encountered in such conditions. Two strategies which circumvent the difficulties ...
  • A leaf-specific phage T7 RNA polymerase-based system for transgene expression in tobacco chloroplasts 

    Magee, Alan (Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2001)
    This thesis describes the development of a chloroplast-localised gene expression system based on the phage T7 RNA polymerase. In order to direct T7 RNAP expression in a leaf-specific manner and to target it to the chloroplast, ...
  • A bioinformatics approach to (intra-) genome comparisons 

    Hokamp, Karsten (Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2002)
    The analysis of large volumes of genomic data generates special computational needs. A Beowulf-type computer cluster was set up for high-performance computing. Improvements over existing tools for the efficient parallelisation of ...

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