RSS 1.0Genetics
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Genetics (Theses and Dissertations)
Recent Submissions
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Detection of pleiotropic repeat expansions and their oligogenic contribution to amyotrophic lateral sclerosis
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)This thesis aims to advance our understanding of the genetic mechanisms that contribute to amyotrophic lateral sclerosis (ALS). The focus is on investigating pleiotropy in genetic contributors to ALS by examining the ... -
Characterisation of the Genetic Mechanism Behind Floral Trichomes in Brassica rapa
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)In his seminal essay ?The Metamorphosis of Plants?, published in the 18th century, Johann Wolfgang von Goethe hypothesized that all above-ground organs of a plant, including floral organs, are derived from leaf-like ... -
Comparing Pathways for Retinal and Neuronal Degeneration in Drosophila melanogaster
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)Past work to understand the mechanisms of cellular degeneration has either focused on retinal degeneration or neurodegeneration. These studies have revealed that the integrated stress response (ISR) and RNA binding proteins ... -
Retrieval of DNA from ancient material and the demography of the extinct aurochs
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)Ancient DNA has revolutionised our understanding of animal genomics by providing direct evidence of the demography of ancient wild populations and unravelling the complex domestication process with time-stamped precision. ... -
Investigation of transcriptome changes during flower development using third-generation sequencing and inducible gene perturbation approaches
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)Over the last 30 years, flower development has been intensively studied us- ing a wide range of genetic and molecular methods. Much of this work was guided by the ABC model of floral organ identity specification, which ...
