Browsing Genetics by Title
Now showing items 410-429 of 544
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Rate asymmetry after genome duplication causes substantial long-branch attraction artifacts in the phylogeny of Saccharomyces species
(Oxford University Press, 2006)Whole-genome duplication (WGD) produces sets of gene pairs that are all of the same age. We therefore expect that phylogenetic trees that relate these pairs to their orthologs in other species should show a single consistent ... -
Rational design of artificial genetic switches : co-option of H-NS-repressed operons by the VirB virulence master regulator
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2012)The H-NS protein represses the transcription of hundreds of genes in Gram-negative bacteria. De-repression is achieved by a multitude of mechanisms, many of which involve binding of a protein to DNA at the repressed promoter ... -
Recent de novo origin of human protein-coding genes.
(2009)The origin of new genes is extremely important to evolutionary innovation. Most new genes arise from existing genes through duplication or recombination. The origin of new genes from noncoding DNA is extremely rare, and ... -
Recent positive selection has acted on genes encoding proteins with more interactions within the whole human interactome
(2015)Genes vary in their likelihood to undergo adaptive evolution. The genomic factors that determine adaptability, however, remain poorly understood. Genes function in the context of molecular networks, with some occupying ... -
Reconstruction of proto-vertebrate, proto-cyclostome and proto-gnathostome genomes provides new insights into early vertebrate evolution.
(2021)Ancient polyploidization events have had a lasting impact on vertebrate genome structure, organization and function. Some key questions regarding the number of ancient polyploidization events and their timing in relation ... -
Relationship among oxidative stress, growth cycle, and sporulation in Bacillus subtilis.
(1987)The sensitivity of Bacillus subtilis to hydrogen peroxide (oxidative stress) was found to vary with the position of the culture in the growth cycle. The most dramatic change occurred at the stationary phase, when the cells ... -
Remarkable complexity and variability of corticospinal tract defects in adult Semaphorin 6A knockout mice
(2019)The corticospinal tract (CST) has a complex and long trajectory that originates in the cerebral cortex and ends in the spinal cord. Semaphorin 6A (Sema6A), a member of the semaphorin family, is an important regulator of ... -
Replication and segregational stability of Bacillus plasmid pBAA1.
(1989)A cryptic plasmid, pBAA1, was identified in an industrial Bacillus strain. The plasmid is 6.8 kilobases in size and is present in cells at a copy number of approximately 5 per chromosome equivalent. The plasmid has been ... -
Rethinking the genetic architecture of schizophrenia
(Cambridge University Press, 2011)Background. For many years, the prevailing paradigm has stated that in each individual with schizophrenia (SZ) the genetic risk is due to a combination of many genetic variants, individually of small effect. Recent empirical ... -
Retrieval of DNA from ancient material and the demography of the extinct aurochs
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)Ancient DNA has revolutionised our understanding of animal genomics by providing direct evidence of the demography of ancient wild populations and unravelling the complex domestication process with time-stamped precision. ... -
Reverse signaling by semaphorin-6A regulates cellular aggregation and neuronal morphology
(2016)The transmembrane semaphorin, Sema6A, has important roles in axon guidance, cell migration and neuronal connectivity in multiple regions of the nervous system, mediated by context-dependent interactions with plexin receptors, ... -
Revisiting AFLP fingerprinting for an unbiased assessment of genetic structure and differentiation of taurine and zebu cattle
(2014)Background Descendants from the extinct aurochs (Bos primigenius), taurine (Bos taurus) and zebu cattle (Bos indicus) were domesticated 10,000 years ago in Southwestern and Southern Asia, respectively, and colonized the ... -
RIPK1 can function as an inhibitor rather than an initiator of RIPK3-dependent necroptosis
(2014)Tumour necrosis factor and lipopolysaccharide can promote a regulated form of necrosis, called necroptosis, upon inhibition of caspase activity in cells expressing receptor-interacting serine/threonine kinase (RIPK)3. ... -
RNA interference-mediated suppression and replacement of human rhodopsin in vivo.
(Elsevier, 2007)Mutational heterogeneity represents a significant barrier to development of therapies for many dominantly inherited diseases. For example, >100 mutations in the rhodopsin gene (RHO) have been identified in patients with ... -
RNAi of COL1A1 in mesenchymal progenitor cells
(Nature Publishing Group, 2004)Given that mutant COL1A1 is known to cause Osteogenesis Imperfecta (OI), tools to modulate COL1A1 expression are likely to be of significant therapeutic value. In this context, we have evaluated RNA interference (RNAi) as ... -
RNP granules-dependent translational regulation in habituation and development
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)Habituation is defined as a reduced behavioral response to a stimulus after repeated or continuous exposure. Long-term habituation (LTH) is a long-lasting form of non-associative memory which is dependent on de novo protein ... -
Rod and cone contributions to horizontal cell light responses in the mouse retina.
(The Society for Neuroscience, 2008)Mammalian B-type horizontal cells make contact with both photoreceptor types: the dendrites contact cone photoreceptors, whereas the axon terminal processes contact rods. Despite their distinct synaptic contacts, horizontal ... -
The role of π?π stacking and hydrogen-bonding interactions in the assembly of a series of isostructural group iib coordination compounds
(2019)The supramolecular chemistry of coordination compounds has become an important research domain of modern inorganic chemistry. Herein, six isostructural group IIB coordination compounds containing a 2-{[(2-methoxyphe ... -
Role of CED-9/cl-2 family proteins in mitochondrial fission and fusion dynamics
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)Programmed cell death in the nematode C. elegans is the equivalent process to human apoptosis. Studying this process in the model organism has led to a great amount of knowledge about the details of pathway steps and ... -
The role of death receptors in ER stress and Inflamation
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Cell death induced in response to ER stress, particularly in response to classical ER stress-inducing agents thapsigargin, brefeldin A and tunicamycin, has been shown to be dependent on the ER stress-dependent upregulation ...
