Caspase and granzyme regulated events in apoptosis and inflammation
Citation:
John Walsh, 'Caspase and granzyme regulated events in apoptosis and inflammation', [thesis], Trinity College (Dublin, Ireland). Department of Genetics, 2011, pp 202Download Item:
Abstract:
The caspase and granzyme proteases are key regulators of both
programmed cell death (apoptosis) and inflammation. They achieve this
regulation through the limited proteolysis of protein substrates, this has
the consequence of altering the function of the targeted proteins.
During the course of apoptotic cell death the activation of the caspase
cascade leads to the processing of hundreds of proteins within the cell
that contribute to its physiological shutdown as well as the packaging of
the dying cell for removal by phagocytes. Upon sensing of microbial patterns or endogenous alarmins, the inflammatory caspases are activated and in turn mediate the activation and release of cytokines such as IL-1β. This work applied molecular, biochemical techniques to explore the activity of these enzymes and define their roles in mediating the above processes.
Author: Walsh, John
Advisor:
Martin, SeamusQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of GeneticsNote:
TARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ieType of material:
thesisAvailability:
Full text availableKeywords:
Genetics, Ph.D., Ph.D. Trinity College Dublin.Metadata
Show full item recordLicences: