Browsing Genetics by Title
Now showing items 477-496 of 544
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The T box regulatory element controlling expression of the class I lysyl-tRNA synthetase of Bacillus cereus strain 14579 is functional and can be partially induced by reduced charging of asparaginyl-tRNAAsn.
(2010)Background Lysyl-tRNA synthetase (LysRS) is unique within the aminoacyl-tRNA synthetase family in that both class I (LysRS1) and class II (LysRS2) enzymes exist. LysRS1 enzymes are found in Archaebacteria and some eubacteria ... -
The tale of a modern animal plague: Tracing the evolutionary history and determining the time-scale for foot and mouth disease virus
(2009)Despite significant advances made in the understanding of its epidemiology, foot and mouth disease virus (FMDV) is among the most unexpected agricultural devastating plagues. While the disease manifests itself as seven ... -
Target 5000: a standardized all-Ireland pathway for the diagnosis and management of inherited retinal degenerations
(2021)Introduction: Inherited retinal degenerations (IRD) are rare genetic disorders with > 300 known genetic loci, mani- festing variably progressive visual dysfunction. IRDs were historically underserved due to lack of effective ... -
Targeting the NLRP3 inflammasome in chronic inflammatory diseases: Current perspectives
(2015)The inflammasome is a molecular platform formed by activation of an innate immune pattern recognition receptor seed, such as NLRP3. Once activated, NLRP3 recruits the adapter ASC (apoptosis-related speck-like protein ... -
Targeting the tight-junctions of the conventional outflow pathway in primary open-angle glaucoma.
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Primary open-angle glaucoma (POAG) is one of the leading causes of blindness worldwide, affecting an estimated 44.1 million people (Tham et al. 2014). POAG is characterised by elevated intraocular pressure (IOP) due to ... -
Testing the hypothesis of genome duplications in vertebrates
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2000)The hypothesis that the human genome has undergone at least two rounds of genome duplication has become widely accepted, but has never been rigorously tested. In this study, several map-based inter- and intra-species ... -
The Chromodomain Helicase DNA binding protein CHD5 is required for neuronal differentiation and repression of non neuronal genes
(Trinity College (Dublin, Ireland). Department of Genetics, 2012)The candidate tumour suppressor gene chromodomain, helicase DNA-binding protein 5 (CHD5) is frequently deleted in neuroblastoma. However, little is known about the role of the CHD5 protein during normal development or its ... -
The development of gene therapy techniques and animal models for Retinitis Pigmentosa and towards the identification of a novel RP-causing gene in a family of Irish origin
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)The work presented in this thesis pertains to several different stages in the preclinical development of therapeutics for inherited retinal disease. Chapter two addresses the difficult challenge of delivery of therapeutics ... -
The double-edged complexity of molecular sequence evolution
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)Traditionally, phylogenetic studies based on sequence data assume simple models of evolution. This is due to computational and time constraints and to our incomplete understanding of the actual complexity of the evolutionary ... -
The essential YycFG two-component system controls cell wall metabolism in Bacillus subtilis
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)The work presented in this thesis describes a comprehensive analysis of the YycFG two-com ponent system (TCS) in Bacillus subtilis. TCSs are widespread mechanisms used by bacteria to sense and respond to the prevailing ... -
The evolution of molecular chaperones and their clients
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2011)Molecular chaperones are ancient and ubiquitous proteins that help other proteins in the cell to fold. In this thesis, we investigate the evolution of assisted protein folding from two perspectives: the evolution of the ... -
The genetics of amyotrophic lateral sclerosis
(Trinity College (Dublin, Ireland). Department of Genetics, 2013)Amyotrophic lateral sclerosis, commonly referred to as motor neuron disease or simply ALS, is a neurological disorder which involves the degeneration of upper and lower motor neurons. The disease is associated with a ... -
The genetics of Mycobacterium bovis infection in Irish cattle
(Trinity College (Dublin, Ireland). Department of Genetics, 2016)Infection of livestock with Mycobacterium bovis, is the causing agent of bovine tuberculosis and is of major economic and health concern globally, with the cost of livestock loss estimated at €2 billion globally. In developed ... -
The identification and functional characterisation of caspase substrates involved in inflammation
(Trinity College (Dublin, Ireland). Department of Genetics, 2010)During inflammation the immune system responds to harmful stimuli, tries to control the stimuli and initiate a healing process for damaged tissue. After recognition of microbes by the innate immune system caspases are ... -
The identification and functional characterization of substrates of the C. elegans caspase CED-3
(Trinity College (Dublin, Ireland). Department of Genetics, 2007)The founding member of the caspase family of proteases is the C. elegans caspase, CED-3. CED-3 is the only caspase required for programmed cell deaths in the worm, but we know very little about how this protease coordinates ... -
The interaction of clumping factor B and iron regulated surface determinants of Staphylococcus aureus with platelets
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2009)Clumping factor B (ClfB) of Staphylococcus aureus is a multi-functional surface protein which binds to cytokeratin 10 and fibrinogen. Cytokeratin 10 is found on the surface of desquamated epithelial cells of the anterior ... -
The interplay between cell death and inflammation
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)The connection between cell death and inflammation is an ancient one, first documented in the first century AD by the roman physician Galen. Cell death, as a consequence of tissue injury or infection, is a potent and ... -
The monocyte protein C pathway : implications in human diseases
(Trinity College (Dublin, Ireland). Department of Genetics, 2004)The protein C (PC) pathway provides an important link between the coagulation, fibrinolytic, and inflammatory pathways. PC/activated protein C (APC) is one o f very few therapies shown to effectively reduce the morbidity ... -
The role of Bcl-2 family in mitochondrial homeostasis
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)Mitochondria are required by cells to generate ATP in order to meet their energy requirements. The electron transport chain, within the mitochondria, pumps protons into the intermembrane space generating an electrochemical ...
