RSS 1.0School of Genetics & Microbiology
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Genetics
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Microbiology
Recent Submissions
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Genetic heterogeneity in amyotrophic lateral sclerosis and related disorders
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)The overarching aim of this thesis is to clarify and further our understanding of the genetic causes of amyotrophic lateral sclerosis (ALS) and related diseases. It is hoped that achieving this can help bring clarity to ... -
Identifying Blood-Brain Barrier Pathologies and Novel Therapeutic Targets in Epilepsy and Neuropsychiatric Disorders
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)The blood-brain barrier (BBB) is vital for maintaining homeostasis of the neural microenvironment. Tight junctions composed of the transmembrane proteins claudin-5 and occludin contribute to the function of this barrier ... -
Investigation of the cellular location of Multicopper Oxidase and its contribution to copper tolerance and immune resistance in Staphylococcus aureus
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2022)In high amounts copper exerts toxic effects on bacteria, and therefore its cellular concentrations must be tightly controlled. Staphylococcus aureus is a WHO priority pathogen responsible of an enormous burden on healthcare ... -
Exploration of gene therapies targeting oxidative stress and NAD+ pathways for the treatment of optic neuropathy
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)The World Health Organisation estimates that there are approximately 300 million people suffering from some form of blindness, from inherited retinal degenerations to complex diseases such as glaucoma. The vast heterogeneity ... -
Using an automated ocular vascular analysis software tool to evaluate the role of the inner blood retinal barrier in AMD pathogenesis and examining its application in neurological disorders
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)Despite being the most common cause of central retinal blindness globally, there is no treatment for end stage dry age related macular degeneration (AMD). The prevailing school of thought with regard to AMD pathogenesis ...
