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  Investigating transcription and the histone methylation landscape in quiescent cells of Saccharomyces cerevisiae 

  Young, Conor (Trinity College (Dublin, Ireland). Department of Microbiology, 2015)

  Eukaryotic genomes are organised as the DNA-protein complex, chromatin within the cell nucleus. The fundamental subunit of chromatin is the nucleosome, which comprises 146 base pairs of DNA wrapped around an octamer of ...
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  MicroRNA regulation of the bovine alveolar macrophage response to Mycobacterium bovis 

  Vegh, Peter (Trinity College (Dublin, Ireland). Department of Genetics, 2015)

  Bovine tuberculosis is one of the most economically significant infectious diseases of cattle in Ireland and globally, resulting in economic losses of approximately €2 billion annually. The causative agent is Mycobacterium ...
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  Genetics of calving performance 

  Purfield, Deirdre Christina (Trinity College (Dublin, Ireland). Department of Genetics, 2015)

  Calving performance is a significant contributor to the profitability of cattle production systems whilst also becoming an increasingly important welfare issue in recent years. Calving performance includes both dystocia ...
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  Sterile inflammation and age-related macular degeneration 

  Ozaki, Ema (Trinity College (Dublin, Ireland). Department of Genetics, 2015)

  Age-related macular degeneration (AMD) is the leading cause of legal blindness in elderly individuals in the developed world, estimated to affect 196 million people worldwide by 2020 (Wong et ai, 2014). AMD primarily affects ...
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  Modulating oxidative stress in the retina using gene therapy as a potential treatment for inherited retinopathies 

  O'Dwyer, Gareth (Trinity College (Dublin, Ireland). Department of Genetics, 2014)

  The focus of this thesis was the exploration of genetic modulators of oxidative stress in transgenic mouse models of Retinitis Pigmentosa (RP). This disease can be inherited both dominantly and recessively and can be either ...

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