RSS 1.0Vice Deanery of Genetics & Microbiology
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Microbiology
Recent Submissions
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Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
(2014)Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to ... -
Autophagy in Multiple Myeloma: What Makes You Stronger Can Also Kill You.
(2013)Autophagy, a process for recycling cellular constituents, is normally associated with cell survival and is thought to be beneficial for tumor maintenance. However, in this issue of Cancer Cell, Lamy and colleagues report ... -
A perspective on mammalian caspases as positive and negative regulators of inflammation.
(2012)Members of the caspase family of cysteine proteases coordinate the morphological and biochemical events that typify apoptosis. However, neutralization of caspase activity in mammals fails to block death in response to ... -
Greasing the path to BAX/BAK activation
(2012)BAX/BAK activation leading to mitochondrial outer-membrane permeabilization is a key commitment point in apoptosis. Chipuk et al. now identify two sphingolipids as specific cofactors for BAX/BAK activation that lower the ... -
Staying alive: defensive strategies in the BCL-2 family playbook.
(2011)Much debate surrounds how prosurvival members of the BCL-2 family repress opening of the BAX/BAK channel to block apoptosis; in this issue Llambi et al. (2011) identify two modes of apoptosis inhibition that exhibit ... -
Oncogene-induced autophagy and the Goldilocks principle
(2011)Although several oncogenes enhance autophagic flux, the molecular mechanism and consequences of onco - gene-induced autophagy remain to be clarified. We have recently shown that expression of oncogenic H-Ras V12 ... -
Oncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic Survival
(2011)Deregulated oncogenes such as MYC and RAS are typically insufficient to transform cells on their own due to the activation of pathways that restrain proliferation. Previous studies have shown that oncogenic H-Ras can induce ... -
Mitochondrial fusion : Bax to the Fussure
(2011)Mitochondria can be organized into highly interconnected networks through continuous cycles of fission and fusion. A recent study by Hoppins et al. (2011) published in Molecular Cell now suggests that Bax, more commonly ... -
A transcription factor network coordinates attraction, repulsion, and adhesion combinatorially to control motor axon pathway selection.
(2014)Combinations of transcription factors (TFs) instruct precise wiring patterns in the developing nervous system; however, how these factors impinge on surface molecules that control guidance decisions is poorly understood. ... -
A GATA/homeodomain transcriptional code regulates axon guidance through the Unc-5 receptor
(2012)Transcription factor codes play an essential role in neuronal specification and axonal guidance in both vertebrate and invertebrate organisms. However, how transcription codes regulate axon pathfinding remains poorly ... -
The homeodomain transcription factor Hb9 controls axon guidance in Drosophila through the regulation of Robo receptors.
(2014)Transcription factors establish neural diversity and wiring specificity; however, how they orchestrate changes in cell morphology remains poorly under- stood. The Drosophila Roundabout (Robo) receptors regulate ... -
Autosis: A new addition to the cell death tower of babel
(2014)Autophagy is a cellular recycling and stress response that degrades organelles and long-lived proteins and serves to protect cells from the potential damage induced by dysfunc- tional organelles and protein aggregates. ... -
An infection-relevant transcriptomic compendium for Salmonella enterica Serovar Typhimurium.
(2013)Bacterial transcriptional networks consist of hundreds of transcription factors and thousands of promoters. However, the true complexity of transcription in a bacterial pathogen and the effect of the environments encountered ... -
Genome architecture and global transcriptional control in bacteria: making progress towards a unified model?
(2013)Data obtained with advanced imaging techniques, chromosome conformation capture methods, bioinformatics and molecular genetics, together with insights from polymer physics and mechanobiology, are helping to refine our ... -
Co-operative roles for DNA supercoiling and nucleoid-associated proteins in the regulation of bacterial transcription
(2013)DNA supercoiling and NAPs (nucleoid-associated proteins) contribute to the regulation of transcription of many bacterial genes. The horizontally acquired SPI (Salmonella pathogenicity island) genes respond positively to ... -
Inhibitor of Apoptosis Proteins (IAPs) and Their Antagonists Regulate Spontaneous and Tumor Necrosis Factor (TNF)-induced Proinflammatory Cytokine and Chemokine Production.
(2013)Inhibitor of apoptosis proteins (IAPs) play a major role in determining whether cells undergo apoptosis in response to TNF as well as other stimuli. However, TNF is also highly proinflammatory through its ability to trigger ... -
Parkin Sensitizes toward Apoptosis Induced by Mitochondrial Depolarization through Promoting Degradation of Mcl-1
(2014)Mitochondrial depolarization promotes Parkin- and PTEN-induced kinase 1 (PINK1)-dependent polyubiquitination of multiple proteins on mitochondrial outer membranes, resulting in the removal of defective mitochondria via ... -
Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy.
(2013)Leber hereditary optic neuropathy (LHON) is a mitochondrially inherited form of visual dysfunction caused by mutations in several genes encoding subunits of the mitochondrial respiratory NADH-ubiquinone oxidoreductase ... -
Whole-transcriptome, high-throughput RNA sequence analysis of the bovine macrophage response to Mycobacterium bovis infection in vitro
(BioMed Central Ltd, 2013)Background Mycobacterium bovis, the causative agent of bovine tuberculosis, is an intracellular pathogen that can persist inside host macrophages during infection via a diverse range of mechanisms that subvert the host ...