Browsing Physiology by Date of Publication
Now showing items 1-20 of 237
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Predictive motor learning of temporal delays.
(1999)Anticipatory responses can minimize the disturbances that result from the action of one part of the body on another. Such a predictive response is evident in the anticipatory increase in grip force seen when one hand ... -
The effects of group II mGluR agonists on short-term depression and neutral coding in the rat dentate gyrus in vitro
(Trinity College (Dublin, Ireland). Department of Physiology, 2000)Short-term depression is an activity-dependent reduction in synaptic efficacy which has been observed at a wide variety of synapses in the CNS, and is often attributed to a depletion of the available store of neurotransmitter. ... -
Endothelial physiology in young cigareete smokers : a multifunctional analysis of the effect of taurine supplementation
(Trinity College (Dublin, Ireland). Department of Physiology, 2000)The aim of this thesis is to determine the impact of cigarette smoking on endothelial dependent integration of the cardiovascular haemodynamic and barrier functions. Considering the antioxidant, anti-inflammatory and ... -
A role for IL-1B in oxidative stress-mediated neuronal impairment
(Trinity College (Dublin, Ireland). Department of Physiology, 2000)The aims of this study were to; (1) investigate age-related changes in the antioxidant defence system in the rat cortex and hippocampus; (2) investigate the role of IL-1β in influencing oxidative stress in brain tissue of ... -
The role of Ca²+ and metabotropic glutamate receptors (mGluRs) in the induction of synaptic plasticity in the rat dentate gyrus in vitro
(Trinity College (Dublin, Ireland). Department of Physiology, 2000)This thesis is about the investigation of some properties of synaptic plasticity in the rat dentate gyrus in vitro. For the experiments brain slices were cut from unanaesthetized rats aged between 3 and 5 weeks. Extracellular ... -
PDZ Proteins interacting with c-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses
(2000)We investigated the role of PDZ proteins (GRIP, ABP, and PICK1) interacting with the C-terminal GluR2 by infusing a ct-GluR2 peptide (“pep2-SVKI”) into CA1 pyramidal neurons in hippocampal slices using whole-cell recordings. ... -
Learning and decay of prediction in object manipulation.
(2000)Anticipating the consequences of our own actions is a fundamental component of normal sensorimotor control and is seen, for example, during the manipulation of objects. When one hand pulls on an object held in the other ... -
Whole-cell but not acellular pertussis vaccines induce convulsive activity in mice: evidence of a role for toxin-induced interleukin-1 beta in a new murine model for analysis of neuronal side effects of vaccination
(American Society for Microbiology, 2001)Immunization with the whole-cell pertussis vaccine (Pw), while effective at preventing whooping cough in infants, has been associated with local, systemic, and neuronal reactions, including fevers and convulsions in children. ... -
The anti-inflammatory cytokine, interleukin (IL)-10, blocks the inhibatory effect of IL-1 beta on long term potentiation - a role for JNK
(2001)Several effects of the proinflammatory cytokine, interleukin-1? (IL-1?), have been described in the central nervous system, and one area of the brain where marked changes have been reported is the hippocampus. Among these ... -
A study of transsynaptic signalling in the hippocampus : a role for nerve growth factor?
(Trinity College (Dublin, Ireland). Department of Physiology, 2001)Long-term potentiation (LTP) is perhaps the best described form of synaptic plasticity. This project aimed to investigate the role that tyrosine kinases play in the expression of LTP in dentate gyrus-granule cell synapses ... -
A role for interleukin-1β in synaptic function
(Trinity College (Dublin, Ireland). Department of Physiology, 2001)The proinflammatory cytokine, interleukin-1β (IL -1β ). one of the most extensively studied cytokines to date, is known to play a pivotal role in neurodegenerative, inflammatory and infectious diseases. Moreover, IL-1β ... -
An investigation into the roles played by interleukin-1Beta and reactive oxygen species in the rat brain during ageing
(Trinity College (Dublin, Ireland). Department of Physiology, 2002)Ageing is associated with an increase in reactive oxygen species production and an increase in the concentration of the pro-inflammatory cytokine interleukin-1β in the hippocampus. These have both been shown to have ... -
A study of the role of neurotrophins in the mechanisms underlying the expression of long-term potentiation in the dentate gyrus
(Trinity College (Dublin, Ireland). Department of Physiology, 2002)Long-term potentiation (LTP) is a well-described form of synaptic plasticity. This study set out to investigate the role that tyrosine kinase plays in the expression of LTP at the perforant path-granule cell synapses of ... -
The PDZ Proteins PICK1, GRIP and Syntenin bind multiple glutamate receptor subtypes
(2002)Using sequence homology searches, yeast two-hybrid assays and glutathione S-transferase (GST)-pull-down approaches we have identified a series of glutamate receptor subunits that interact differentially with the PDZ proteins ... -
Effects of acute and chronic exercise on autonomic cardiovascular control and endothelial function in young and older healthy male subjects
(Trinity College (Dublin, Ireland). Department of Physiology, 2002)Exercise training is known to reduce resting blood pressure ; however, the underlying mechanisms have yet to be fully elucidated. The main objective of this thesis was to investigate the effects of exercise in two parameters ... -
Mechanism of inhibition of LTP induction by preconditioning stimulation in the rat dentate gyrus in vitro
(Trinity College (Dublin, Ireland). Department of Physiology, 2003)The modulation of synaptic plasticity (LTP) by prior synaptic activity represented by preconditioning stimulation (weak HFS) was investigated in the medial perforant pathway of the dentate gyrus in vitro. The inhibition ... -
Rapid and differential regulation of AMPA and kainite receptors at hippocampal mossy fibre synapses by PICK1 and GRIP
(2003)We identified four PDZ domain-containing proteins, syntenin, PICK1, GRIP, and PSD95, as interactors with the kainate receptor (KAR) subunits GluR52b, GluR52c, and GluR6. Of these, we show that both GRIP and PICK1 interactions ... -
An investigation into the effect of A beta on cultured cortical neurons
(Trinity College (Dublin, Ireland). Department of Physiology, 2003)Accumulation of the endogenously produced beta-amyloid (Aβ) peptide in senile plaques is involved in the development of Alzheimer’s disease. This study reports on potential molecular mechanisms underlying the cell death ... -
The cellular protein level of Parkin is regulated by its ubiquitin-like domain
(2003)Parkin is a ubiquitin-protein isopeptide ligase (E3) involved in ubiquitin/proteasome-mediated protein degradation. Mutations in the parkin gene cause a loss-of-function and/or alter protein levels of parkin. As a result, ...