RSS 1.0Physiology
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Physiology (Theses and Dissertations)
Recent Submissions
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Assessing Toll-like receptor 3/4 signalling as a phytocannabinoid target in immune cells
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2020)Toll-like receptors (TLRs) are the sensors of pathogen associated molecules that trigger tailored innate immune intracellular signalling responses. TLRs are expressed on cells of the immune system and play an important ... -
Investigating the Effects of FTY720 on Spatial Memory and Neuroinflammation in a Rodent Model of Alzheimer's Disease
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2020)Alzheimer's disease (AD) is a progressive, age-related neurodegenerative disorder characterized by memory loss and cognitive decline, with loss of global functioning over time eventually leading to death. At the molecular ... -
Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid
(2018)Background: Microglia are multifunctional cells that are primarily neuroprotective and a deficit in their functional integrity is likely to be a contributory factor in the deteriorating neuronal function that occurs with ... -
Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice.
(2019)Among the changes that typify Alzheimer’s disease (AD) are neuroinflammation and microglial activation, amyloid deposition perhaps resulting from compromised microglial function and iron accumulation. Data from Genome Wide ... -
Monocytes exposed to plasma from patients with Alzheimer's disease undergo metabolic reprogramming
(2019)The search for a blood-based biomarker that identifies Alzheimer’s disease (AD) and can replace current invasive and expensive diagnostic tests, continues. The most extensively-examined peripheral marker is β-amyloid (Aβ) ...
