RSS 1.0Physiology
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Physiology (Scholarly Publications)
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Physiology (Theses and Dissertations)
Physiology (Theses and Dissertations)
Recent Submissions
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Investigating the role of mechanosensitive channel Piezo1 in the CNS
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2019)All cells in the organism are able to sense changes in the mechanical properties of their environment, translating them into chemical intracellular signals through a process termed mechanotransduction, mostly via ... -
A study of the role of neurotrophins in the mechanisms underlying the expression of long-term potentiation in the dentate gyrus
(Trinity College (Dublin, Ireland). Department of Physiology, 2002)Long-term potentiation (LTP) is a well-described form of synaptic plasticity. This study set out to investigate the role that tyrosine kinase plays in the expression of LTP at the perforant path-granule cell synapses of ... -
The role of Ca²+ and metabotropic glutamate receptors (mGluRs) in the induction of synaptic plasticity in the rat dentate gyrus in vitro
(Trinity College (Dublin, Ireland). Department of Physiology, 2000)This thesis is about the investigation of some properties of synaptic plasticity in the rat dentate gyrus in vitro. For the experiments brain slices were cut from unanaesthetized rats aged between 3 and 5 weeks. Extracellular ... -
An investigation into the effect of A beta on cultured cortical neurons
(Trinity College (Dublin, Ireland). Department of Physiology, 2003)Accumulation of the endogenously produced beta-amyloid (Aβ) peptide in senile plaques is involved in the development of Alzheimer’s disease. This study reports on potential molecular mechanisms underlying the cell death ... -
Effects of smoking and ageing on cardiovascular function
(Trinity College (Dublin, Ireland). Department of Physiology, 2004)Ageing and smoking have both been identified as important risk factors for cardiovascular morbidity and mortality. The aim of these studies was to investigate the effects of ageing and smoking on autonomic and endothelial ...
