RSS 1.0Physiology
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Physiology (Theses and Dissertations)
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Effects on an acute priming exercise and high-intensity interval training on oxygen uptake and muscle deoxygenation kinetics in older individuals with type 2 diabetes
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2021)Peak oxygen uptake (V̇O2peak) is consistently reduced in individuals with type 2 diabetes (T2D) of all ages compared with non-diabetic (ND) controls. In middle-aged (between 45 to 60 y) individuals with T2D these reductions ... -
Elucidating the complex organization of neural micro-domains in the locust Schistocerca gregaria using dMRI
(2021)To understand brain function it is necessary to characterize both the underlying structural connectivity between neurons and the physiological integrity of these connections. Previous research exploring insect brain ... -
From Mechanisms to Analgesia: Towards the Use of Non-Invasive Neuromodulation for Pain Relief in the Clinic
(Intech Open, 2020)The use of electricity for analgesic effects has a long history and yet currently neuromodulation devices based on electrical stimulation are typically restricted to being a last resort intervention for pain patients after ... -
The interactions of apolipoprotein E and inflammation in human iPSC-derived astrocytes
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2020)Alzheimer’s disease (AD) is a devastating neurodegenerative disease characterised histologically by the presence of extracellular plaques and intracellular neurofibrillary tangles, and clinically by memory ... -
Targeting the Sphingosine 1-Phosphate Axis as a Therapeutic Strategy in Krabbe's Disease: A Pre-Clinical Study.
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2020)Krabbe's disease (KD, globoid cell leukodystrophy) is a rare infantile neurodegenerative disorder, caused by the defective gene galc encoding the lysosomal hydrolase galactosylceramidase (GALC). A subsequent decreased ...
