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  Identifying the therapeutic potential of novel compounds in the treatment of Glioblastoma Multiforme 

  Keenan, Emily (Trinity College Dublin. School of Medicine. Discipline of Physiology, 2023)

  Glioblastoma multiforme (GBM) is the most common and aggressive brain cancer in adults with a dismal 5-year survival rate of <5%. Despite advanced diagnostic and multimodal treatments including surgery, followed by ...
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  Antipsychotics Prevent Psychosine Induced Toxicity in Glial Cells. 

  Sharma, Kapil (Trinity College Dublin. School of Medicine. Discipline of Physiology, 2023)

  Glial cells are implicated in the neuropathophysiology of schizophrenia and other neuropsychiatric disorders. Also, the role of altered myelin in the onset and development of schizophrenia and changes in myelin due to ...
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  Low-volume HIIT and MICT speed VO2 kinetics during high-intensity "work-to-work" cycling with a similar time-course in type 2 diabetes 

  Gildea, Norita; Egana, Mikel (2022)

  We assessed the rates of adjustment in oxygen uptake (V̇o2) and muscle deoxygenation [i.e., deoxygenated hemoglobin and myoglobin, (HHb + Mb)] during the on-transition to high-intensity cycling initiated from an elevated ...
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  Priming exercise accelerates oxygen uptake kinetics during high-intensity cycle exercise in middle-aged individuals with type 2 diabetes 

  Egana, Mikel (2022)

  Background: The primary phase time constant of pulmonary oxygen uptake kinetics ( ⋅VO2 τ p) during submaximal efforts is longer in middle-aged people with type 2 diabetes (T2D), partly due to limitations in oxygen supply ...
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  Exploring Sex-Related Differences in Microglia May Be a Game-Changer in Precision Medicine 

  Lynch, Marina (2022)

  One area of microglial biology that has been relatively neglected until recently is sex differences and this is in spite of the fact that sex is a risk factor in several diseases that are characterized by neuroinflammation ...

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