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The PDZ Proteins PICK1, GRIP and Syntenin bind multiple glutamate receptor subtypes
(2002)Using sequence homology searches, yeast two-hybrid assays and glutathione S-transferase (GST)-pull-down approaches we have identified a series of glutamate receptor subunits that interact differentially with the PDZ proteins ... -
Rapid and differential regulation of AMPA and kainite receptors at hippocampal mossy fibre synapses by PICK1 and GRIP
(2003)We identified four PDZ domain-containing proteins, syntenin, PICK1, GRIP, and PSD95, as interactors with the kainate receptor (KAR) subunits GluR52b, GluR52c, and GluR6. Of these, we show that both GRIP and PICK1 interactions ... -
PDZ Proteins interacting with c-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses
(2000)We investigated the role of PDZ proteins (GRIP, ABP, and PICK1) interacting with the C-terminal GluR2 by infusing a ct-GluR2 peptide (“pep2-SVKI”) into CA1 pyramidal neurons in hippocampal slices using whole-cell recordings. ... -
Inhibition of the Interaction Between Group I Metabotropic Glutamate Receptors and PDZ-Domain Proteins Prevents Hippocampal Long-Term Depression, but Not Long-Term Potentiation
(2019-04-18)The group I metabotropic glutamate (mGlu) receptor subtypes, mGlu1 and mGlu5, strongly regulate hippocampal synaptic plasticity. Both harbor PSD-95/discs-large/ZO-1 (PDZ) motifs at their extreme carboxyl terminals, which ... -
Effects of high -intensity interval vs moderate-intensity continous training on the time course adapations in cardiovascular fitness and oxygen uptake kinetics in type 2 diabetes
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2019)Individuals with type 2 diabetes mellitus (T2DM) present with significant impairments in the dynamic and peak responses of pulmonary oxygen uptake (V̇O2) during exercise. Both low-volume high-intensity interval training ...
