Browsing Physiology by Title
Now showing items 1-20 of 236
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A 2.5min cold water immersion improves prolonged intermittent sprint performance
(2019)Objectives: We investigated if cold water immersion (CWI) affects exercise performance during a prolonged intermittent sprint test (IST), designed to mimic activity patterns of team-sports. Design: Randomized-crossover ... -
α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR.
(2015)The immunoregulatory function of single-Ig-interleukin-1 related receptor (SIGIRR) is derived from its ability to constrain the inflammatory consequences of interleukin (IL)-1R and toll-like receptor (TLR)4 activation. ... -
A role for amyloid-β in Alzheimer's pathology : evidence from cellular, animal and pre-clinical studies
(Trinity College (Dublin, Ireland). Department of Physiology, 2012)One of the well-documented histopathological features of Alzheimer’s disease (AD) is the progressive accumulation of amyloid-β (Aβ) within the brain, thought to result from inefficient clearance of Aβ by phagocytes and/or ... -
A role for IL-1B in oxidative stress-mediated neuronal impairment
(Trinity College (Dublin, Ireland). Department of Physiology, 2000)The aims of this study were to; (1) investigate age-related changes in the antioxidant defence system in the rat cortex and hippocampus; (2) investigate the role of IL-1β in influencing oxidative stress in brain tissue of ... -
A role for interleukin-1β in synaptic function
(Trinity College (Dublin, Ireland). Department of Physiology, 2001)The proinflammatory cytokine, interleukin-1β (IL -1β ). one of the most extensively studied cytokines to date, is known to play a pivotal role in neurodegenerative, inflammatory and infectious diseases. Moreover, IL-1β ... -
A study of neuroinflammation in a mouse model of Alzheimer's disease
(Trinity College (Dublin, Ireland). Department of Physiology, 2010)Microglia are the principal immune-competent cell of the central nervous system (CNS) and there is evidence to suggest microglia are the co-ordinating cells of the CNS inflammatory response. The blood brain barrier (BBB) ... -
A study of the potential of adult mesenchymal stem cells in bone and cartilage tissue engineering
(Trinity College (Dublin, Ireland). Department of Physiology, 2006)Adult mesenchymal stem cells (MSCs) have the potential to self-renew and differentiate into bone, cartilage, fat and muscle cells. This cell population offers significant potential for engineering of musculoskeletal tissue. ... -
A study of the role of neurotrophins in the mechanisms underlying the expression of long-term potentiation in the dentate gyrus
(Trinity College (Dublin, Ireland). Department of Physiology, 2002)Long-term potentiation (LTP) is a well-described form of synaptic plasticity. This study set out to investigate the role that tyrosine kinase plays in the expression of LTP at the perforant path-granule cell synapses of ... -
A study of transsynaptic signalling in the hippocampus : a role for nerve growth factor?
(Trinity College (Dublin, Ireland). Department of Physiology, 2001)Long-term potentiation (LTP) is perhaps the best described form of synaptic plasticity. This project aimed to investigate the role that tyrosine kinases play in the expression of LTP in dentate gyrus-granule cell synapses ... -
Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1beta-induced inhibition of long-term potentiation in rat dentate gyrus
(2003)Lipopolysaccharide (LPS), a component of the cell wall of Gram-negative bacteria, has been shown to induce profound changes both peripherally and centrally. It has recently been reported that intraperitoneal injection of ... -
Adenosine A(2A) receptors control neuroinflammation and consequent hippocampal neuronal dysfunction.
(2011)The blockade of adenosine A2A receptors (A2AR) affords a robust neuroprotection in different noxious brain conditions. However, the mechanisms underlying this general neuroprotection are unknown. One possible mechanism ... -
The age- and amyloid-beta-related increases in Nogo B contribute to microglial activation
(2011)The family of reticulons include 3 isoforms of the Nogo protein, Nogo A, Nogo B and Nogo C. Nogo A is expressed on neuronal tissue and its primary effect is widely acknowledged to be inhibition of neurite outgrowth. Although ... -
Age-associated dysregulation of microglial activation is coupled with enhanced BBB permeability and pathology in APP/PS1 mice
(2014)Aging adversely affects inflammatory processes in the brain, which has important implications in the context of disease progression. It has been proposed that microglia become dysfunctional with age and may lose their ... -
Age-related changes in the hippocampus (loss of synaptophysin and glial-synaptic interaction) are modified by systemic treatment with an NCAM-derived peptide, FGL
(2012)Altered synaptic morphology, progressive loss of synapses and glial (astrocyte and microglial) cell activation are considered as characteristic hallmarks of ageing. Recent evidence suggests that there is a concomitant ... -
The age-related deficit in LTP is associated with changes in perfusion and blood-brain barrier permeability.
(2012)In view of the increase in the aging population and the unavoidable parallel increase in the incidence of age-related neurodegenerative diseases, a key challenge in neuroscience is the identification of clinical signatures ... -
The Age-related Gliosis and Accompanying Deficit in Spatial Learning are Unaffected by Dimebon.
(2013)A non-selective antihistamine, dimebon, has recently emerged as a potential treatment for Alzheimer's disease and Huntington's disease. Dimebon exerts several effects in addition to its anti-histaminergic effect, and of ... -
Age-related neuroinflammatory changes negatively impact on neuronal function.
(2010)Neuroinflammatory changes, characterized by an increase in microglial activation and often accompanied by upregulation of inflammatory cytokines like interleukin-1? (IL-1?), are common to many, if not all, neurodegenerative ... -
Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization.
(2008)The current development of immunotherapy for Alzheimer's disease is based on the assumption that human-derived amyloid beta protein (Abeta) can be targeted in a similar manner to animal cell-derived or synthetic Abeta. ... -
Amyloid precursor protein knockdown by siRNA impairs spontaneous alternation in adult mice.
(2007)The cleavage-product of amyloid precursor protein (APP) constitutes the core component of plaques found in the brains of Alzheimer's disease (AD) patients. APP is ubiquitously expressed and its precise physiological functions ...