A role for interleukin-1β in synaptic function
Citation:
Emily Vereker, 'A role for interleukin-1β in synaptic function', [thesis], Trinity College (Dublin, Ireland). Department of Physiology, 2001, pp 348Download Item:
Vereker TCD THESIS 6174 A role.pdf (PDF) 243.9Mb
Abstract:
The proinflammatory cytokine, interleukin-1β (IL -1β ). one of the most
extensively studied cytokines to date, is known to play a pivotal role in
neurodegenerative, inflammatory and infectious diseases. Moreover, IL-1β has been
implicated in the impairment of long-term potentiation (LTP), a model for learning
and memory, and at least one biochemical correlate associated with LTP, i.e.,
glutamate release. The mechanisms underlying the impairment of LTP in deleterious
circumstances, such as in ageing, remains to be fully elucidated. The focus of this
study involved investigating the possibility that the stress-activated protein kinases,
JNK and p38, underlie this impairment and that activation is initiated by an increase
in IL -1β concentration and reactive oxygen species (ROS) formation.
Author: Vereker, Emily
Advisor:
Lynch, MarinaQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of PhysiologyNote:
TARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.iePrint thesis water damaged as a result of the Berkeley Library Podium flood 25/10/2011
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Physiology, Ph.D., Ph.D. Trinity College DublinLicences: