• Tumour Tissue Microenvironment Can Inhibit Dendritic Cell Maturation in Colorectal Cancer 

  O'SULLIVAN, JACINTHA (2011)

  Inflammatory mediators in the tumour microenvironment promote tumour growth, vascular development and enable evasion of anti-tumour immune responses, by disabling infiltrating dendritic cells. However, the constituents ...
• An Exploratory Spatial Analysis of ALS Incidence in Ireland over 17.5 Years (1995 - July 2013). 

  HARDIMAN, ORLA (2014)

  Abstract Introduction There has been much interest in spatial analysis of ALS to identify potential environmental or genetically caused clusters of disease. Results to date have been inconclusive. The Irish ALS register ...
• Effectiveness of community health workers delivering preventive interventions for maternal and child health in low- and middle-income countries: a systematic review. 

  MC AULIFFE, EILISH (2013)

  Background Community Health Workers are widely utilised in low- and middle-income countries and may be an important tool in reducing maternal and child mortality; however, evidence is lacking on their effectiveness for ...
• Head of household education level as a factor influencing whether delivery takes place in the presence of a skilled birth attendant in Busia, Uganda: a cross-sectional household study 

  MC AULIFFE, EILISH (2013)

  Background Assistance during delivery by a skilled attendant is recommended as a means to reduce child and maternal mortality. Globally, higher levels of maternal education have been associated with better health ...
• Mid-level providers in emergency obstetric and newborn health care: factors affecting their performance and retention within the Malawian health system 

  MC AULIFFE, EILISH (2009)

  BACKGROUND: Malawi has a chronic shortage of human resources for health. This has a significant impact on maternal health, with mortality rates amongst the highest in the world. Mid-level cadres of health workers provide ...
• A Systematic Review of the Effectiveness of Alternative Cadres in Community Based Rehabilitation 

  MC AULIFFE, EILISH (2012)

  BACKGROUND: The Millennium Development Goals (MDGs) aim to improve population health and the quality and dignity of people's lives, but their achievement is constrained by the crisis in human resources for health. An ...
• Validation of the self-reported hearing questions in the Irish Longitudinal Study on Ageing against the Whispered Voice Test. 

  KENNY, ROSE ANNE; CRONIN, HILARY (2014)

  BACKGROUND: Self report questions are often used in population studies to assess sensory efficacy and decline. These questions differ in their validity in assessing sensory impairment depending on the wording of the ...
• Targeting T cell immunometabolism for cancer immunotherapy; understanding the impact of the tumor microenvironment. 

  O'NEILL, LUKE ANTHONY JOHN (2014)

  The immune system has a key role to play in controlling cancer initiation and progression. T cell activation, which is central to anti-tumor immune responses, coincides with changes in cellular metabolism. Naïve T cells ...
• A prospective cohort study of alcohol exposure in early and late pregnancy within an urban population in Ireland 

  BARRY, JOSEPH; MURPHY, DEIRDRE (2014)

  Most studies of alcohol consumption in pregnancy have looked at one time point only, often relying on recall. The aim of this longitudinal study was to determine whether alcohol consumption changes in early and late pregnancy ...
• A retrospective cohort study of mode of delivery among public and private patients in an integrated maternity hospital setting. 

  MURPHY, DEIRDRE (2013)

  Abstract Objective To examine the associations between mode of delivery and public versus privately funded obstetric care within the same hospital setting. Design Retrospective cohort study. Setting Urban maternity ...
• Study protocol. IDUS - Instrumental delivery &; ultrasound: a multi-centre randomised controlled trial of ultrasound assessment of the fetal head position versus standard care as an approach to prevent morbidity at instrumental delivery. 

  MURPHY, DEIRDRE (2012)

  Background Instrumental deliveries are commonly performed in the United Kingdom and Ireland, with rates of 12 – 17% in most centres. Knowing the exact position of the fetal head is a pre-requisite for safe instrumental ...
• Behavioural change in relation to alcohol exposure in early pregnancy and impact on perinatal outcomes--a prospective cohort study. 

  BARRY, JOSEPH; MURPHY, DEIRDRE (2013)

  Background There has been limited research addressing whether behavioural change in relation to alcohol exposure in pregnancy results in better perinatal outcomes. Methods A cohort study of 6725 women who booked for ...
• Antidepressants are Independently Associated with Gait Deficits in Single and Dual Task Conditions 

  KENNY, ROSE ANNE (2014)

  Objectives This study examined the relationships between late-onset depressive symptoms, antidepressants, and single and dual task gait in older adults. Design Cross-sectional study. Setting The Irish Longitudinal ...
• Is low iron status a risk factor for neural tube defects? 

  MOLLOY, ANNE MARIE (2014)

  Background: Folic acid supplements can protect against neural tube defects (NTDs). Low folate and low vitamin B12 status may be maternal risk factors for having an NTD affected pregnancy. However, not all NTDs are preventable ...
• The frailty index in Europeans: assocation with age and mortality. 

  ROMERO-ORTUNO, ROMAN; KENNY, ROSE ANNE (2012)

  BACKGROUND: the frailty index (FI) is an approach to the operationalisation of frailty based on accumulation of deficits. It has been less studied in Europeans. OBJECTIVE: to construct sex-specific FIs from a large ...
• Inappropriate prescribing in older fallers presenting to an Irish emergency department. 

  KENNY, ROSE ANNE (2014)

  BACKGROUND: certain medications increase falls risk in older people. OBJECTIVE: to assess if prescribing modification occurs in older falls presenting to an emergency department (ED). DESIGN: before-and-after ...
• A functional variant of the serotonin transporter gene (SLC6A4) moderates impulsive choice in attention-deficit/hyperactivity disorder boys and siblings. 

  ANNEY, RICHARD JAMES LEON; GILL, MICHAEL (2011)

  BACKGROUND: Impulsive drive for immediate reward (IDIR) and delay aversion are dissociable elements of the preference for immediate over delayed rewards seen in attention-deficit/hyperactivity disorder (ADHD). We ...
• Common Variants at ABCA7, MS4A6A/MS4A4E, EPHA1/CD33 and CD2AP are associated with Alzheimer's disease 

  GILL, MICHAEL (2011)

  We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium (ADGC) in a companion ...
• Epistasis between neurochemical gene polymorphisms and risk for ADHD 

  HAWI, ZIARIH; GILL, MICHAEL (2011)

  A number of genes with function related to synaptic neurochemistry have been genetically associated with attention deficit/hyperactivity disorder. However, susceptibility to the development of common psychiatric disorders ...
• Fine mapping of ZNF804A and genomime-wide significant evidence for it's involvement in Schizophrenia and bipolar disorder. 

  CORVIN, AIDEN PETER; MORRIS, DEREK; GILL, MICHAEL (2011)

  A recent genome-wide association study (GWAS) reported evidence for association between rs1344706 within ZNF804A (encoding zinc-finger protein 804A) and schizophrenia (P=1.61 × 10(-7)), and stronger evidence when the ...

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