Modulation of innate immunity by the vaccinia virus protein K7 and its target DDX3
Citation:
Orla Mulhern, 'Modulation of innate immunity by the vaccinia virus protein K7 and its target DDX3', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010, pp 272Download Item:
Abstract:
Vaccinia virus (VACV) has many mechanisms to subvert and modulate the host
immune response. One well characterised VACV protein that does this is A52. K7
was found from a search of the VACV genome looking for genes with sequence
similarities to A52. A52 is known to modulate IL-1 and TLR signalling and
contributes to virulence. Like A52, K7 can inhibit interleukin-1 (IL-1) and toll-like
receptor (TLR) signalling leading to NFkB aetivation. In addition both K7 and A52
can induce IL-10, an anti-inflammatory cytokine, to modulate the host response to
VACV.
Author: Mulhern, Orla
Advisor:
Bowie, AndrewQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Biochemistry and ImmunologyNote:
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Full text availableKeywords:
Biochemistry, Ph.D., Ph.D. Trinity College Dublin.Metadata
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