• Enriched CD141+ DCs in the joint are transcriptionally distinct, activated, and contribute to joint pathogenesis. 

  Fletcher, Jean; Fearon, Ursula (2018)

  CD141+ DC are implicated in antiviral and antitumor immunity. However, mechanisticstudies in autoimmune disease are limited. This is the first study to our knowledgeexamining CD141+ DC in autoimmune disease, specifically ...
• Altered metabolic pathways regulate synovial inflammation in rheumatoid arthritis. 

  Fletcher, Jean; Fearon, Ursula (2018)

  Rheumatoid arthritis is characterized by synovial proliferation, neovascularization and leucocyte extravasation leading to joint destruction and functional disability. The blood vessels in the inflamed synovium are highly ...
• Plant-derived polyphenols modulate human dendritic cell metabolism and immune function via AMPK-dependent induction of heme oxygenase-1 

  Fletcher, Jean; Dunne, Aisling (2019-03-01)

  Polyphenols are important immunonutrients which have been investigated in the context of inflammatory and autoimmune disease due to their significant immunosuppressive properties. However, the mechanism of action of many ...
• Differential regulation of human Treg and Th17 cells by fatty acid synthesis and glycolysis 

  Phelan, Andreea; Fletcher, Jean (2019)

  In this study we examined the metabolic requirements of human T helper cells and the effect of manipulating metabolic pathways in Th17 and Treg cells. The Th17:Treg cell axis is dysregulated in a number of autoimmune or ...
• Rab32 interacts with SNX6 and affects retromer-dependent Golgi trafficking 

  Khan, Amir (Public Library of Science, 2019)

  The Rab family of small GTPases regulate various aspects of cellular dynamics in eukaryotic cells. Membrane trafficking has emerged as central to the functions of leucine-rich repeat kinase 2 (LRRK2), which is associated ...

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