Biochemistry
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Biochemistry (Scholarly Publications)
Biochemistry (Scholarly Publications) -
Biochemistry (Theses and Dissertations)
Biochemistry (Theses and Dissertations)
Recent Submissions
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Metabolic and redox regulation of IL-17-producing γδ T cells
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)Interleukin-17 (IL-17) is a proinflammatory cytokine that contributes to a wide range of immune responses, including host defence, tissue repair, autoimmune inflammation, and tumour progression. γδ17 T cells (CD3+TCRδ+CD27-) ... -
The function and regulation of IL-17A-producing T cell subsets in central nervous system autoimmunity
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)Multiple sclerosis (MS) is a chronic progressive autoimmune disease of the central nervous system (CNS). MS is characterised by the presence of demyelinating lesions in the CNS and is the leading cause of disability among ... -
Effect of small molecules modulators of Complex III of the electron transport chain on cytokine production in macrophages
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)Innate immune cells promote inflammation when activated by Pathogen- associated molecular patterns (PAMPs) and initiate the immune response to stress and microbial invasion. When macrophages are primed with the ... -
Investigating sex differences in the mitochondria of CD4+ and CD8+ T lymphocytes
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)Sex differences in immunity have been observed in many contexts including infectious diseases, cancer, and autoimmunity. Females generally mount stronger innate and adaptive responses, and as a result tend to have lower ... -
Unravelling the inflammatory landscape of hidradenitis suppurativa
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)Hidradenitis suppurativa (HS) is a chronic, relapsing, inflammatory skin disease characterised by painful lesions at hair follicles of the inframammary fold, genitals, groin, buttocks and perianal areas. Follicular ...