RSS 1.0Biochemistry
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Biochemistry (Scholarly Publications)
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Biochemistry (Theses and Dissertations)
Recent Submissions
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Innate resistance to hepatitis C virus infection in the Irish anti-D cohort
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Even within homogenous populations, outcome following exposure to a virus can vary substantially. This continuum of infection outcome spans viral resistance, spontaneous resolution and chronic infection, with further ... -
A study of bioenergetics and mitochondrial function in Cytotoxic T cell subsets
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)CD8 T cell fate and function have been linked to specific metabolic programs. T effector (T eff) and T memory (T mem) cells engage mitochondrial metabolism to different extents, as recognised by stark differences in ... -
Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response
(2022)To overcome oxidative, inflammatory, and metabolic stress, cells have evolved cytoprotective protein networks controlled by nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) and its negative regulator, Kelch-like ECH ... -
Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages
(2022)Activated macrophages undergo metabolic reprogramming, which not only supports their energetic demands but also allows for the production of specific metabolites that function as signaling molecules. Several Krebs cycles, ... -
The role of itaconate in host defense and inflammation
(2022)Macrophages exposed to inflammatory stimuli including LPS undergo metabolic reprogramming to facilitate macrophage effector function. This metabolic reprogramming supports phagocytic function, cytokine release, and ROS ...
