dc.contributor.advisor | Bowie, Andrew | |
dc.contributor.author | Mulhern, Orla | |
dc.date.accessioned | 2019-11-13T11:58:59Z | |
dc.date.available | 2019-11-13T11:58:59Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | Orla Mulhern, 'Modulation of innate immunity by the vaccinia virus protein K7 and its target DDX3', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010, pp 272 | |
dc.identifier.other | THESIS 9456 | |
dc.identifier.uri | http://hdl.handle.net/2262/90424 | |
dc.description.abstract | Vaccinia virus (VACV) has many mechanisms to subvert and modulate the host
immune response. One well characterised VACV protein that does this is A52. K7
was found from a search of the VACV genome looking for genes with sequence
similarities to A52. A52 is known to modulate IL-1 and TLR signalling and
contributes to virulence. Like A52, K7 can inhibit interleukin-1 (IL-1) and toll-like
receptor (TLR) signalling leading to NFkB aetivation. In addition both K7 and A52
can induce IL-10, an anti-inflammatory cytokine, to modulate the host response to
VACV. | |
dc.format | 1 volume | |
dc.language.iso | en | |
dc.publisher | Trinity College (Dublin, Ireland). School of Biochemistry and Immunology | |
dc.relation.isversionof | http://stella.catalogue.tcd.ie/iii/encore/record/C__Rb14882909 | |
dc.subject | Biochemistry, Ph.D. | |
dc.subject | Ph.D. Trinity College Dublin. | |
dc.title | Modulation of innate immunity by the vaccinia virus protein K7 and its target DDX3 | |
dc.type | thesis | |
dc.type.supercollection | thesis_dissertations | |
dc.type.supercollection | refereed_publications | |
dc.type.qualificationlevel | Doctoral | |
dc.type.qualificationname | Doctor of Philosophy (Ph.D.) | |
dc.rights.ecaccessrights | openAccess | |
dc.format.extentpagination | pp 272 | |
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