Recent Submissions

  • Adrenergic, Circadian, and Dietary Regulation of Interleukin-17A Expression by Adipose Gamma-Delta T Cells 

    Douglas, Aaron Keith (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)
    Adipose tissue is home to a unique population of IL-17A expressing Gamma-Delta T cells (Gamma-Delta17 T cells), which are necessary for maintaining body temperature during cold environmental temperatures. However, the ...
  • Pre-clinical development of NOX2/ROS blood-based biomarker of TBI 

    Emediato, Isabella Dias (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)
    There is an urgent need to develop predictive biomarkers for traumatic brain injury (TBI) to aid clinical diagnosis and treatment of head injury patients. NADPH oxidase 2 (NOX2) activity and oxidized biomarkers are being ...
  • Characterisation of Innate Immune and Metabolic Roles of SARM1 in Mouse Macrophages. 

    Shanahan, Katharine Ann (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)
    Engagement of the NLRP3 inflammasome in response to injury or infection results in the activation of the pro-inflammatory protease, caspase-1. Cleavage of the caspase-1 substrate, gasdermin D (GSDMD), leads to the GSDMD ...
  • Single cell analysis of iNKT cell heterogeneity, phenotype, and function 

    Kane, Harry (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)
    Innate T cells, including CD1d-restricted invariant natural killer T (iNKT) cells, are characterized by their rapid activation in response to non-peptide antigens, such as lipids. While the transcriptional profiles of ...
  • The role of tissue-resident memory T cells in immunity to Bordetella pertussis 

    Curham, Lucy (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)
    Whooping cough (pertussis) is a severe respiratory disease cause by the Gram-negative bacterium Bordetella pertussis. Despite high vaccine coverage, a resurgence of pertussis has been observed over recent years. Although ...

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