Recent Submissions

  • The circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2 

    EARLY, JAMES ORMAN (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)
    The response of the innate immune system to an inflammatory insult is largely dependent on time-of-day, and many inflammatory conditions are associated with dysfunctional molecular clocks within immune cells. However, the ...
  • An examination of the molecular control of feed efficiency in beef cattle 

    MCKENNA, CLARE (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)
    Global agriculture is faced with the enormous challenge of feeding a rapidly growing population while being cognizant of the environmental footprint of such endeavours. A consequence of increased meat consumption worldwide ...
  • HUMAN HEPATIC NATURAL KILLER CELLS IN HEALTH AND MALIGNANCY 

    HARMON, CATHAL (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)
    The adult human liver is described as an immunologically tolerogenic organ, maintaining a homeostatic environment while bombarded by dietary antigens, microbial products and metabolic by-products. The liver is also a site ...
  • Biochemical characterization of the human queine insertase complex 

    AL-QASEM, MASHAEL ABDULLAH (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)
    Queuine is a bacterial metabolite that is salvaged by almost all eukaryotic species including algae, yeast, fungi and metazoans and is incorporated into transfer RNA for the amino acids asparagine, aspartic acid, histidine ...
  • The role of IL-1 and Type I IFN in CNS function 

    MURRAY, CAROL (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)
    Cytokines including interleukins (ILs) and interferons (IFNs) are induced in response to tissue injury, infection or inflammation. Peripheral cytokines signal to the healthy Central Nervous System (CNS) to produce ...

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