Recent Submissions

  • Modulation of immune responses by Fasciola hepatica-derived products 

    WALSH, ROBERT JAMES (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)
    Helminths are successful pathogens that infect 25% of the world s population. They cause chronic infections that are associated with type-2 and regulatory immune responses that suppress host anti-parasite immune responses. ...
  • Immunomodulatory therapies for autoimmune diseases 

    SULAIMANI, JAMAL (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)
    Multiple sclerosis (MS) and psoriasis are both T cell mediated autoimmune diseases that are triggered in genetically susceptible individuals in response to environmental factors. Th17 cells are strongly implicated in the ...
  • Factors influencing the induction of immune responses with DNA vaccines 

    Daly, Lyn M. (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2002)
    Compared with any other medical discovery vaccines have prevented more deaths and suffering. Emergence of novel pathogens accentuates the requisite for ongoing development and improvement of traditional vaccination strategies. ...
  • An investigation into the expression and physiological function of mitochondrial uncoupling proteins 

    Carroll, Audrey (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2004)
    Our study provides evidence that rat thymus contains a functioning mitochondrial uncoupling protein (UCP 1). Using reverse transcriptase-polymerase chain reaction (RT-PCR), we showed that rat thymus contains UCP 1 mRNA. ...
  • Analysis of the MAPK pathways, in silico and in vitro 

    Caffrey, Daniel Richard (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2002)
    This thesis takes a combined computational and experimental approach to study the MAPK pathways. These proteins were chosen as they are highly conserved in both sequence and function across all eukaryotes. An evolutionary ...

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