Recent Submissions

  • Activation and function of mucosal gamma delta T cells 

    Misiak, Alicja (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)
    γδ T cells are innate-like lymphocytes characterised by rapid activation following infection or tissue injury. They are enriched in the skin and epitheliae of various organs, where breach of the barrier is likely to occur. ...
  • Role of infection and T cells in disease pathogenesis in a model of Alzheimer's disease 

    McManus, Róisín M. (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)
    Alzheimer's disease (AD) is a progressive neurodegenerative disease characterised by deposits of amyloid-β (Aβ) and neurofibrillary tangles. It has been suggested that inflammatory changes are associated with disease, ...
  • The characterisation of Human Vδ3 T cells 

    Mangan, Bo (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)
    Human γδ T cells expressing the Vδ3 TCR make up a minor lymphocyte subset in blood but are enriched in liver and in patients with some chronic viral infections and leukemias. We analysed the frequencies, phenotypes, ...
  • Induction of regulatory immune responses that control autoimmune diseases 

    Malara, Anna (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)
    Regulatory T (Treg) cells play a fundamental role in suppressing excessive inflammatory responses to pathogens and in maintaining peripheral tolerance to self-antigens. A breakdown in self-tolerance or defect in Treg cells ...
  • Evaluation of the anti-cancer effects of novel pyrrolo-1, 5-benzoxazepines in neuroblastoma 

    Lennon, Jennifer (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)
    Neuroblastoma, a malignancy of neuroectodermal origin, accounts for 15% of childhood cancer deaths. Despite both advances in understanding the biology of the cancer and aggressive treatment strategies, it continues to be ...

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