Recent Submissions

  • Investigation of the mechanism of action and the therapeutic potential of peptides derived from the vaccinia virus protein A46 

    Lysakova-Devine, Tatyana (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)
    The innate arm of the mammalian immune system employs a number of pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs), which recognise pathogen associated molecular patterns (PAMPs) and initiate ...
  • Evolution of human Natural Killer cell receptors 

    Guinan, Kieran (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)
    Natural Killer (NK) cells are key components of the innate immune system which function in identifying and destroying aberrant or infected cells. They also play active roles in human reproduction. These functions are largely ...
  • Manipulating regulatory responses in antitumour immunity 

    Galvin, Karen (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)
    The immune system has evolved tolerogenic and regulatory mechanism to control responses to self-antigens and to ensure that the inflammatory immune response to pathogens does not cause excessive tissue damage during ...
  • Immunotherapeutics & vaccine adjuvants for cancer 

    Corcoran, Anna-Maria B. (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)
    It is well established that innate immune responses not only mediate immunity to infection, but also promotes adaptive immunity to pathogens and tumours. Dendritic cells (DC) play a critical role as antigen presenting cells ...
  • Computational approaches to the display and manipulation of metabolic pathways : theory and practice 

    Connolly, James Joseph (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2008)
    Since metabolic pathways constitute a complex system, a mathematical description, even a structural one, must be simplified. Yet, the model must be sufficiently general so that it will encompass the system that is to be ...

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