RSS 1.0Biochemistry (Theses and Dissertations)
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Delineating the mechanisms utilised by Staphylococcus aureus to survive intracellularly within phagocytes
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Staphylococcus aureus (S. aureus) is a major human pathogen in addition to being an important part of the human microbiome. The bacterium has evolved a large array of immune evasion mechanisms to facilitate its persistence ... -
Antiviral activity of human hepatocytes and its regulation by cellular antioxidant systems
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Although several antiviral strategies have been developed in the last decade, hepatotropic viruses are still a significant public health burden, with more than 300 million people being affected worldwide. Hepatocytes, the ... -
Immunopathological features of early age cancer: microsatellite instability in colorectal cancer
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Title: Immunopathological features of early age cancer: microsatellite instability in colorectal cancer Background and hypothesis Deciphering the interplay between tumour biology and the immune system may aid the design ... -
Investigation of Staphylococcus aureus-induced immunosuppression during nasal colonisation and the implications for vaccine function
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Staphylococcus aureus (S. aureus) is a major part of the natural human microbiome, primarily colonising the anterior nares. The overall aim of this project was to determine the impacts nasal colonisation has on local and ... -
Oxysterols - new players in regulation of Natural Killer cells
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Natural Killer (NK) cells are cytotoxic, innate lymphocytes that play a crucial role in mediating viral and tumour responses as well as supporting tissue homeostasis. Due to their fast acting immune response independent ...
