Recent Submissions

  • Characterisation of T cell responses during Staphylococcus aureus infection 

    Murphy, Alison (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)
    The development of anti-S. aureus vaccines has consistently failed in clinical trials, likely due to inefficient induction of cellular immunity. A comprehensive understanding of the discrete T cell subsets critical for ...
  • DHX9 : novel roles in cytokine induction and its antagonism by vaccinia virus protein E3 

    Dempsey, Alan (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)
    Vaccinia virus (VACV) is a dsDNA virus, which replicates in the cytoplasm of infected host cells. VACV, similar to other viruses, is detected by host innate immunity mainly by sensing of viral nucleic acids such as dsRNA, ...
  • An integrated approach to oral vaccination against enteric pathogens 

    Davitt, Christopher (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)
    While the majority of human pathogens infect the body through mucosal sites, most licenced vaccines are injectable. In fact the only mucosal vaccine that is widely used for infant and childhood vaccination programs is the ...
  • In vivo and ex vivo examination of the safety of oats in coeliac disease 

    Cooper, Sarah (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)
    Coeliac disease is a chronic autoimmune disorder of the small intestine characterised by infiltration of intraepithelial lymphocytes, crypt hyperplasia and villous atrophy. It develops in genetically susceptible individuals ...
  • An investigaton of the innate immune response to the vaccine adjuvant chitosan 

    Carroll, Elizabeth (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)
    Vaccination is widely regarded as one of the most successful medical intervention strategies to have been introduced. Despite its resounding success, significant challenges in the field of vaccine research still remain. ...

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