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  • Mutational and phenotypic analysis of hyperphenylalaninaemia in Southern Ireland 

    O'Donnell, Kate (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)
    Phenylketonuria (PKU) is the most common inherited defect of amino acid metabolism in the Irish population occurring at a frequency of 1/4,500 live births. It is caused by a deficiency of the hepatic enzyme Phenylalanine ...
  • Differential patterns of gene expression associated with microsatellite instability and chromosomal instability in colorectal cancer 

    Dunican, Donncha St. John (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)
    Two distinct pathways exist in sporadic colorectal cancer. The microsatellite instability pathway (MIN) is recognised by widespread instability caused by aberrant mismatch repair machinery. This genotype accounts for 15% ...
  • Differential patterns of gene expression associated with metastasis in colon cancer 

    Parle-McDermott, Anne (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)
    Metastatic spread is the main cause of colon cancer related death and therefore a greater understanding of this process is a prerequisite for improved treatment. The acquisition of metastatic properties confers tumour cells ...
  • Biochemical investigations of hyperhomocysteinemia 

    Betts, Mary Victoria (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)
    Hyperhomocysteinemia, a condition where plasma homocysteine occurs at an abnormally elevated level, is a common finding in vascular disease subjects. Several genetic and nutritional factors have been implicated. The first ...
  • Modulation of the inflammatory response by taurine and its structural analogue, HEPES 

    Brennan, Cara (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)
    Activated neutrophils (PMNs) have been implicated in the production of tissue injury in inflammatory-bowel disease (IBD) through release of proinflammatory mediaters during respiratory burst activity. Taurine, the most ...
  • The role of thiols in the activation of the platelet integrin αllbβ3 

    O'Neill, Sarah (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2001)
    Platelets play a vital role in maintaining normal haemostasis. They circulate passively in the blood in an non-adhesive slate as discrete smooth discs. When platelets encounter a vessel wall injury or are exposed to foreign ...
  • Is Apolipoprotein-E modulated in peripheral blood mononuclear cells by IFN-β and is this to related patient responsiveness in multiple sclerosis 

    O'Toole, Daniel (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2001)
    Multiple Sclerosis is a neurodegenerative disorder involving the attack of blood resident T-lymphocytes on the myelin sheath surrounding the neuron. This condition is particularly prevalent amongst white, northern European ...
  • The establishment of hybrid cell lines from human pancreas 

    Reid, George W. (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2001)
    The need for research into diabetes mellitus is ever increasing. Of specific interest are the mechanisms responsible for glucose-responsive insulin secretion and the autoimmune destruction of pancreatic p-cells. However, ...
  • Studies on human biliverdin-IX alpha reductase and linear tetrapyrrole signaling 

    Dunne, Aisling (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2001)
    Human Biliverdin-IXa reductase (BVR-A) has been cloned and overexpressed in E.coli as a GST- and Hexahistidine fusion protein. The full length cDNA encoding the enzyme has been amplified via PCR and hgated into the pGEX-KG ...
  • Studies on muscle residues of the anti-bacterial veterinary medicines tilmicosin, enrofloxacin and tiamulin in livestock and the risk to consumers from ingestion of injection-sites 

    Beechinor, Jeremiah Gabriel (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2001)
    Studies on incurred residues of the veterinary anti-bacterials tilmicosin, enrofloxacin and tiamulin were undertaken in cattle, sheep and pigs in order to investigate the effects of cooking on injection-site residues and ...
  • Factors influencing the induction of immune responses with DNA vaccines 

    Daly, Lyn M. (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2002)
    Compared with any other medical discovery vaccines have prevented more deaths and suffering. Emergence of novel pathogens accentuates the requisite for ongoing development and improvement of traditional vaccination strategies. ...
  • Analysis of the MAPK pathways, in silico and in vitro 

    Caffrey, Daniel Richard (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2002)
    This thesis takes a combined computational and experimental approach to study the MAPK pathways. These proteins were chosen as they are highly conserved in both sequence and function across all eukaryotes. An evolutionary ...
  • Characterisation of signalling pathways activated by the IL-1 receptor homologue T1/ST2 

    Brint, Elizabeth (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2003)
    T1/ST2 is a member of the IL-1 receptor family possessing the three characteristic extracellular Ig domains and an intracellular Toll-IL1R (TIR) domain. It is an orphan receptor expressed on a variety of cell types including ...
  • Modulation of immune responses by filamentous haemagglutinin from Bordetella pertussis 

    McCann, Chantelle (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2004)
    The aim of this study was to investigate the mechanisms by which filamentous haemagglutinin (FHA) from Bordetella pertussis modulates immune responses. FHA is an adhesion molecule of B. pertussis and facilitates bacterial ...
  • Trafficking and regulation of the serotonin transporter 

    Magnani, Francesca (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2004)
    The serotonin transporter (SERT) is responsible for the clearance of serotonin from the synaptic cleft. Together with the norepinephrine transporter and dopamine transporter, SERT is of great interest because it is the ...
  • Immediate-Early-Gene (IEG) expression in excitotoxicity 

    Rogers, Annamarie (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2004)
    The mouse cerebellar granule cell system (mCGCs; Schousboe et al, 1989) was established in this laboratory (Bayer AG, Germany) as a suitable cell culture model for excitotoxicity studies. Suitability was confirmed by ...
  • An investigation into the expression and physiological function of mitochondrial uncoupling proteins 

    Carroll, Audrey (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2004)
    Our study provides evidence that rat thymus contains a functioning mitochondrial uncoupling protein (UCP 1). Using reverse transcriptase-polymerase chain reaction (RT-PCR), we showed that rat thymus contains UCP 1 mRNA. ...
  • Local cellular and humoral immunity to Bordetella pertussis 

    Byrne, Patricia (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2004)
    The development of whole cell vaccine (Pw) and acellular pertussis vaccines (Pa) has had a huge impact on the incidence of whooping cough worldwide. The traditional Pw had high protective efficacy, but were associated with ...
  • Investigations into the physiological expression of UCP1 and UCP3 

    Brennan, Clare M. (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2005)
    Previous studies have indicated that acute exercise induces large increases in uncoupling protein 3 in skeletal muscle, whereas endurance training results in marked decreases in skeletal muscle uncoupling protein 3 at both ...
  • Activation of innate immunity by Bordetella pertussis 

    Higgins, Sarah (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2005)
    Respiratory infection with Bordetella pertussis is associated with the induction of Th1 cells and these cells, as well as antibody and cells of the innate immune system mediate the clearance of bacteria from the lungs. ...