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  • A role for eIF4A1 in IL-10 induction by LPS 

    Alam, M. Mustafa (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)
    microRNAs are a family of short non-coding RNAs that act as fine tuners of gene expression by controlling mRNAs. They have been implicated in numerous diseases including inflammatory diseases. A number of studies have ...
  • A role for microRNA-21 in the regulation of gastrointestinal health and disease 

    Johnston, Daniel (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2017)
    The gastrointestinal (GI) tract is a crucial site of innate and adaptive immune regulation, balancing tolerance of beneficial commensal microorganisms and reaction to invading pathgens. Pattern recognition receptors (PRRs), ...
  • A study of the effects of neurotoxins on the activity and copper of Ceruloplasmin 

    Healy, Joseph (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2006)
    This thesis focuses on the ability of neurotoxins to affect the activity of the copper transport protein ceruloplasmin (EC 1.16.3.1; ferroxidase) and its intrinsic oxidase activities. The protective properties of taurine ...
  • A study of the multiple functions and interactions of semicarbazide sensitive amine oxidase 

    O'Sullivan, Jeffrey (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2005)
    This thesis focuses on three of the recognised multiple functions of mammalian semicarbazide sensitive amine oxid ase (SSAO) and the contribution of monoamine oxidase (MAO) to some of these. SSAO is a vascular-adhesion ...
  • Activation and function of mucosal gamma delta T cells 

    Misiak, Alicja (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)
    γδ T cells are innate-like lymphocytes characterised by rapid activation following infection or tissue injury. They are enriched in the skin and epitheliae of various organs, where breach of the barrier is likely to occur. ...
  • Activation of innate immunity by Bordetella pertussis 

    Higgins, Sarah (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2005)
    Respiratory infection with Bordetella pertussis is associated with the induction of Th1 cells and these cells, as well as antibody and cells of the innate immune system mediate the clearance of bacteria from the lungs. ...
  • Adjuvants targeting innate T lymphocytes for improved oral vaccination 

    ALBUTTI, AQEL SULAIMAN (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)
    Effective mucosal vaccines can provide protective local and systemic immunity. Oral vaccination in particular has the potential to offer a safer and more efficacious approach than injection-based approaches, especially ...
  • An integrated approach to oral vaccination against enteric pathogens 

    Davitt, Christopher (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)
    While the majority of human pathogens infect the body through mucosal sites, most licenced vaccines are injectable. In fact the only mucosal vaccine that is widely used for infant and childhood vaccination programs is the ...
  • An investigation into the expression and physiological function of mitochondrial uncoupling proteins 

    Carroll, Audrey (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2004)
    Our study provides evidence that rat thymus contains a functioning mitochondrial uncoupling protein (UCP 1). Using reverse transcriptase-polymerase chain reaction (RT-PCR), we showed that rat thymus contains UCP 1 mRNA. ...
  • An investigaton of the innate immune response to the vaccine adjuvant chitosan 

    Carroll, Elizabeth (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)
    Vaccination is widely regarded as one of the most successful medical intervention strategies to have been introduced. Despite its resounding success, significant challenges in the field of vaccine research still remain. ...
  • An Analysis of Glutathionylation in the Modulation of the Critical Innate Immune Regulators Mal and NEK7 

    HUGHES, MARK (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)
    Macrophages are critical innate immune cells that sense pathogen associated molecular patterns (PAMPs) and host-derived damage associated molecular patterns (DAMPs) through specialized Toll-like receptors (TLRs) to maintain ...
  • Analysis of mitochondrial proteomes and supercomplex structures in brain tissue 

    Brady, Laura (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)
    Mitochondria play a complex multifactorial role in the control of cell bioenergetics. A primary function of mitochondria is the production of adenosine 5'-triphosphate (ATP) by the process of oxidative phosphorylation that ...
  • Analysis of the MAPK pathways, in silico and in vitro 

    Caffrey, Daniel Richard (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2002)
    This thesis takes a combined computational and experimental approach to study the MAPK pathways. These proteins were chosen as they are highly conserved in both sequence and function across all eukaryotes. An evolutionary ...
  • Biochemical characterization of the human queine insertase complex 

    AL-QASEM, MASHAEL ABDULLAH (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)
    Queuine is a bacterial metabolite that is salvaged by almost all eukaryotic species including algae, yeast, fungi and metazoans and is incorporated into transfer RNA for the amino acids asparagine, aspartic acid, histidine ...
  • Biochemical investigations of hyperhomocysteinemia 

    Betts, Mary Victoria (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)
    Hyperhomocysteinemia, a condition where plasma homocysteine occurs at an abnormally elevated level, is a common finding in vascular disease subjects. Several genetic and nutritional factors have been implicated. The first ...
  • Bioenergetics and mitochondrial dynamics in cancer cells and neurons 

    Quinn, Stephen (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)
    Mitochondria in mammalian cells exist as a highly dynamic and interconnected reticulum. This reticular ultrastructure is defined by the opposing forces of fission and fusion, mainly mediated by a group of large GTPases ...
  • Biophysical Investigations of the Specificity between Rab GTPases and their Effectors 

    KEARNEY, AOIFE MAIREAD (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)
    The specificity of protein-protein interactions is a complex process that is poorly understood and difficult to predict. Understanding the molecular basis for specificity of a protein and its binding partner requires a ...
  • Characterisation of signalling pathways activated by the IL-1 receptor homologue T1/ST2 

    Brint, Elizabeth (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2003)
    T1/ST2 is a member of the IL-1 receptor family possessing the three characteristic extracellular Ig domains and an intracellular Toll-IL1R (TIR) domain. It is an orphan receptor expressed on a variety of cell types including ...
  • Characterisation of T cell responses during Staphylococcus aureus infection 

    Murphy, Alison (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)
    The development of anti-S. aureus vaccines has consistently failed in clinical trials, likely due to inefficient induction of cellular immunity. A comprehensive understanding of the discrete T cell subsets critical for ...
  • Characterisation of the novel leucine rich repeat containing protein KIAA0644 

    Carpenter, Susan (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2008)
    This thesis reports the existence o f a novel leucine rich repeat containing protein annotated as KIAA0644 in the Kazusa DNA Research Institute database (www.Kazusa.or.jp). which was discovered in a study for proteins ...