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  • A biochemical oscillator : experimental and theoretical studies of the peroxidase-oxidase reaction 

    McDonald, Andrew (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)
    The peroxidase-oxidase (PO) reaction is the haem-peroxidase catalysed reaction of molecular oxygen with NADH, and has been shown previously to behave in an oscillatory fashion. It has been used here as a useful laboratory ...
  • A comparative genomics analysis of the vertebrate immune system : genes, pathways and evolution 

    Cormican, Paul (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)
    All species possess a selection-honed collection of genes whose products function in unison to form a barricade to invading pathogens. The exponential increase in publicly available sequence data has allowed the application ...
  • A role for eIF4A1 in IL-10 induction by LPS 

    Alam, M. Mustafa (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)
    microRNAs are a family of short non-coding RNAs that act as fine tuners of gene expression by controlling mRNAs. They have been implicated in numerous diseases including inflammatory diseases. A number of studies have ...
  • A role for microRNA-21 in the regulation of gastrointestinal health and disease 

    Johnston, Daniel (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2017)
    The gastrointestinal (GI) tract is a crucial site of innate and adaptive immune regulation, balancing tolerance of beneficial commensal microorganisms and reaction to invading pathgens. Pattern recognition receptors (PRRs), ...
  • A role for type 111 interferons in the natural killer cell immune response to virus 

    Morrison, Maria H. (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)
    Natural Killer (NK) cells are fundamental effector cells of the innate immune system that function to eliminate virally infected and transformed cells. One key way in which they do this is through the production of cytokines, ...
  • A structural study of ALgE, transporter of alginate from Pseudomonas aeruginosa PAOI 

    Tan, Jingquan (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)
    Pseudomonas aeruginosa is an opportunistic human pathogen that causes serious diseases in humans with immune system deficiencies, such as cystic fibrosis, wound infections, urinary tract infections, and blood stream ...
  • A study of the effects of neurotoxins on the activity and copper of Ceruloplasmin 

    Healy, Joseph (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2006)
    This thesis focuses on the ability of neurotoxins to affect the activity of the copper transport protein ceruloplasmin (EC 1.16.3.1; ferroxidase) and its intrinsic oxidase activities. The protective properties of taurine ...
  • A study of the glycosylphosphatidylinositol phospholipase C in Trypanosoma brucei 

    O'Byrne, Robert (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)
    Trypanosoma brucei represents a clade of flagellated parasites that cause human and animal trypanosomiases in sub-Saharan Africa. The glycosylphosphatidylinositol phospholipase C (GPI-PLC) is an endogenous enzyme that has ...
  • A study of the multiple functions and interactions of semicarbazide sensitive amine oxidase 

    O'Sullivan, Jeffrey (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2005)
    This thesis focuses on three of the recognised multiple functions of mammalian semicarbazide sensitive amine oxid ase (SSAO) and the contribution of monoamine oxidase (MAO) to some of these. SSAO is a vascular-adhesion ...
  • Activation and function of mucosal gamma delta T cells 

    Misiak, Alicja (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)
    γδ T cells are innate-like lymphocytes characterised by rapid activation following infection or tissue injury. They are enriched in the skin and epitheliae of various organs, where breach of the barrier is likely to occur. ...
  • Activation of innate immunity by Bordetella pertussis 

    Higgins, Sarah (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2005)
    Respiratory infection with Bordetella pertussis is associated with the induction of Th1 cells and these cells, as well as antibody and cells of the innate immune system mediate the clearance of bacteria from the lungs. ...
  • Adjuvants targeting innate T lymphocytes for improved oral vaccination 

    ALBUTTI, AQEL SULAIMAN (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)
    Effective mucosal vaccines can provide protective local and systemic immunity. Oral vaccination in particular has the potential to offer a safer and more efficacious approach than injection-based approaches, especially ...
  • An integrated approach to oral vaccination against enteric pathogens 

    Davitt, Christopher (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)
    While the majority of human pathogens infect the body through mucosal sites, most licenced vaccines are injectable. In fact the only mucosal vaccine that is widely used for infant and childhood vaccination programs is the ...
  • An investigation into the expression and physiological function of mitochondrial uncoupling proteins 

    Carroll, Audrey (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2004)
    Our study provides evidence that rat thymus contains a functioning mitochondrial uncoupling protein (UCP 1). Using reverse transcriptase-polymerase chain reaction (RT-PCR), we showed that rat thymus contains UCP 1 mRNA. ...
  • An investigation into the physiological expression and function of mitochondrial uncoupling protein 1 in thymus 

    Adams, Alison Elizabeth (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)
    Our study confirms the presence of mitochondrial uncoupling protein 1 in thymus. Using laser scanning confocal microscopy, we showed the constitutive expression of UCP 1 in pure thymocytes. Using a primary peptide antibody ...
  • An investigation into the role and regulation of uncoupling protein 1 (UCP 1) 

    Clarke, Kieran John (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)
    The use of the uncoupling protein inhibitor GDP was used to investigate UCP 1 dependent ROS production in BAT and thymus mitochondria. The effect of UCP 1 inhibition by GDP was then corroborated using UCP 1 ablated mice ...
  • An investigation into the role of TLR4 interactor with leucine rich repeats (TRIL) in Toll-like receptor responses in brain 

    Wochal, Paulina (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)
    TLR4 interactor with leucine rich repeats (TRIL) was originally described as a protein required for Toll-like receptor 4 (TLR4) signalling. This thesis provides new insights into the function of TRIL within TLR signalling ...
  • An investigation into the role of TMED1 in IL-33/ST2L singalling pathway 

    Connolly, Dympna (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)
    This thesis set out to characterise the GOLD domain containing protein, TMED1 which had been shown to associate with ST2L, the receptor for the cytokine IL-33 and to investigate its relationship with ST2L.
  • An investigation of the link between the bacterial derived queuine molecule and tyrosine production 

    Rakovich, Tatsiana (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)
    Queuine, a dietary derived 7-deazaguanine molecule, has previously been shown to prevent lethality and other symptoms in germ-free mice that were maintained on a tyrosine-free diet. This work suggested a link between queuine ...
  • An investigation of the physiological and pathological role of uncoupling proteins 

    Manzke, Lars (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)
    Uncoupling proteins (UCPs) are found in numerous different tissues and have been associated with many physiological and pathological conditions. After decades of research on uncoupling proteins, there is still only a modest ...