dc.contributor.advisor | Bracken, Adrian | |
dc.contributor.author | Jerman, Emilia | |
dc.date.accessioned | 2019-11-06T16:21:26Z | |
dc.date.available | 2019-11-06T16:21:26Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Emilia Jerman, 'Identification and characterisation of a novel Polycomb Repressive Complex 2 associated protein that is an alternatively spliced product of the LCOR gene locus', [thesis], Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2015, pp 158 | |
dc.identifier.other | THESIS 10942 | |
dc.identifier.uri | http://hdl.handle.net/2262/90244 | |
dc.description.abstract | Polycombs are evolutionary conserved epigenetic regulators crucial for
specification of cell types during development. They assemble in multiprotein
complexes to modify amino terminal tails of histone H3 at lysine 27 to regulate the
expression of underlying genes. PRC2 mediates repression by catalysing trimethylation
of histone H3 at lysine 27 (H3K27me) at the promoters of master
transcriptional regulators, such as HOX and cell cycle and proliferation regulating
genes. Recently, it emerged that PRC2 also mediates the mono-and dimethylation
of H3K27 and that these histone marks are associated with gene
activation and enhancer silencing, respectively. | |
dc.format | 1 volume | |
dc.language.iso | en | |
dc.publisher | Trinity College (Dublin, Ireland). School of Genetics and Microbiology | |
dc.relation.isversionof | http://stella.catalogue.tcd.ie/iii/encore/record/C__Rb16683951 | |
dc.subject | Genetics & Microbiology, Ph.D. | |
dc.subject | Ph.D. Trinity College Dublin. | |
dc.title | Identification and characterisation of a novel Polycomb Repressive Complex 2 associated protein that is an alternatively spliced product of the LCOR gene locus | |
dc.type | thesis | |
dc.type.supercollection | thesis_dissertations | |
dc.type.supercollection | refereed_publications | |
dc.type.qualificationlevel | Doctoral | |
dc.type.qualificationname | Doctor of Philosophy (Ph.D.) | |
dc.rights.ecaccessrights | openAccess | |
dc.format.extentpagination | pp 158 | |
dc.description.note | TARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie | |