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  • Novel therapeutic strategies for autosomal dominant retinitis pigmentosa 

    O'Neill, Brian G. D. (Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2000)
    A major difficulty associated with the design of gene therapies for autosomal dominant diseases is the immense intragenic heterogeneity often encountered in such conditions. Two strategies which circumvent the difficulties ...
  • Therapeutic approaches to halting photoreceptor cell death in the retina 

    Tuohy, Gearóid Patrick (Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2001)
    Retinitis pigmentosa (RP) is a group of hereditary retinopathies affecting approximately 1 in 3500 people in the developed world. The disorders are characterised by the early onset of night blindness followed by a progressive ...
  • A leaf-specific phage T7 RNA polymerase-based system for transgene expression in tobacco chloroplasts 

    Magee, Alan (Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2001)
    This thesis describes the development of a chloroplast-localised gene expression system based on the phage T7 RNA polymerase. In order to direct T7 RNAP expression in a leaf-specific manner and to target it to the chloroplast, ...
  • Comparative analysis of human and mouse acute phase Serum Amyloid A gene expresseion 

    Thorn, Caroline F. (Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2001)
    The Serum Amyloid A (S AA) proteins are a family of highly conserved lipoproteins secreted by the liver. Their production and release is massively induced under conditions of inflammation or infection by pro-inflammatory ...
  • Evolution of vertebrate genome organisation 

    McLysaght, Aoife (Trinity College (Dublin, Ireland). Department of Genetics, 2002)
    The increasing availability of genomic sequences from different vertebrate organisms affords molecular biologists the opportunity to thoroughly investigate phenomena that were only hinted at by more sparse data. The work ...
  • A bioinformatics approach to (intra-) genome comparisons 

    Hokamp, Karsten (Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2002)
    The analysis of large volumes of genomic data generates special computational needs. A Beowulf-type computer cluster was set up for high-performance computing. Improvements over existing tools for the efficient parallelisation of ...
  • Genetic investigation of Irish ancestry and surname history 

    McEvoy, Brian Patrick (Trinity College (Dublin, Ireland). Department of Genetics, 2005)
    Several genetic systems were employed in this study to investigate Ireland’s pre-history and history. Initially Irish origins were examined using mtDNA sequence variation in 200 new samples coupled with an extensive novel ...
  • Different patterns of gain and loss in genomic evolution 

    González Knowles, David (Trinity College (Dublin, Ireland). Department of Genetics, 2008)
    Evolutionary forces may act on the genome at different levels, from the change of single nucleotides to the duplication or rearrangement of whole chromosomes. Some of these evolutionary processes can be responsible for ...
  • Explorations of miRNA expression in the mammalian retina 

    Loscher, Carol Jane (Trinity College (Dublin, Ireland). Department of Genetics, 2009)
    MicroRNAs (miRs) are an abundant class of non-coding RNAs which, for the most part were undiscovered until early this decade (Lagos-Quintana et al. 2001; Lee et al. 2001). Mature miR transcripts are small (~22 nucleotides) ...
  • Complex evolutionary dynamics in simple genomes: the paradoxical survival of intracellular symbiotic bacteria 

    Toft, Christina (Trinity College (Dublin, Ireland). Department of Genetics, 2009)
    Symbiosis is one of the ways in which nature has been able to generate biological innovation by fusing two organisms with different complexities. Because of these differing complexities, many problems for both organisms ...
  • Comparative analysis of poxvirus genome evolution 

    Bratke, Kirsten (Trinity College (Dublin, Ireland). Department of Genetics, 2010)
    In this thesis I examine the molecular evolution of poxviruses using various comparative genomics approaches. Poxviruses are large DNA viruses that infect vertebrates and insects. Understanding the evolutionary processes ...
  • Function and evolution of genes in the human protein interaction network 

    Pérez-Bercoff, Åsa (Trinity College (Dublin, Ireland). Department of Genetics, 2012)
    The research conducted for this thesis aims to elucidate how the human protein interaction network has evolved, and how protein interactions influence the spatial organisation of the metabolic network. The thesis presents ...
  • The Chromodomain Helicase DNA binding protein CHD5 is required for neuronal differentiation and repression of non neuronal genes 

    Egan, Chris M. (Trinity College (Dublin, Ireland). Department of Genetics, 2012)
    The candidate tumour suppressor gene chromodomain, helicase DNA-binding protein 5 (CHD5) is frequently deleted in neuroblastoma. However, little is known about the role of the CHD5 protein during normal development or its ...
  • The genetics of amyotrophic lateral sclerosis 

    Kenna, Kevin (Trinity College (Dublin, Ireland). Department of Genetics, 2013)
    Amyotrophic lateral sclerosis, commonly referred to as motor neuron disease or simply ALS, is a neurological disorder which involves the degeneration of upper and lower motor neurons. The disease is associated with a ...
  • The role of Polycomb Repressive Complex 2 associated proteins in mediating complex recruitment 

    Brien, Gerard L. (Trinity College (Dublin, Ireland). Department of Genetics, 2013)
    All multi-cellular organisms are constructed from a myriad of distinct cell types, each performing specialized functions. With very few exceptions all cell types contain the same genetic information encoded in the genome. ...
  • On the development of molecular approaches to therapy for retinitis pigmentosa 

    Nguyen, Anh Thi Hong (Trinity College (Dublin, Ireland). Department of Genetics, 2013)
    Endothelial cells lining the microvasculature of the retina have highly evolved “tight junctions” reducing the space between adjacent cells to form a selective and highly regulatable barrier called the inner blood-retina ...
  • Transcriptional regulation by the ubiquitin system in model plant Arabidopsis thaliana 

    Hanczaryk, Katarzyna (Trinity College (Dublin, Ireland). Department of Genetics, 2014)
    In eukaryotes, the ubiquitin (Ub) system controls protein stability and regulates many developmental and physiological processes, in part through the regulation of transcription. Recent data show that some components of ...
  • Investigation of the immunophilin interactome of malarial parasites 

    Leneghan, Darren (Trinity College (Dublin, Ireland). Department of Genetics, 2014)
    Malaria presents a significant global challenge in both human and economic terms. Approximately 40% of the population of the planet are at risk of contracting malaria, leading to an estimated 225 million cases and ...
  • Examination of transcriptional regulation and functional roles of axon guidance receptors in Drosophila dorsal vessel formation 

    Asadzadeh Tabrizi, Jamshid (Trinity College (Dublin, Ireland). Department of Genetics, 2014)
    Early steps of cardiogenesis in vertebrates and invertebrates are similar in that in both systems, bilateral rows of cardiac progenitors migrate towards a point where the two rows meet and make a tubular structure. As with ...
  • Genetic diagnosis and treatment of inherited retinopathies 

    Carrigan, Matthew (Trinity College (Dublin, Ireland). Department of Genetics, 2014)
    The first goal of this PhD was to improve and optimize a gene therapy based on the yeast protein Ndi 1 for Leber's Hereditary Optic Neuropathy (LHON), a mitochondrially-inherited retinal disorder. LHON is an incompletely ...