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  • Novel therapeutic strategies for autosomal dominant retinitis pigmentosa 

    O'Neill, Brian G. D. (Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2000)
    A major difficulty associated with the design of gene therapies for autosomal dominant diseases is the immense intragenic heterogeneity often encountered in such conditions. Two strategies which circumvent the difficulties ...
  • A leaf-specific phage T7 RNA polymerase-based system for transgene expression in tobacco chloroplasts 

    Magee, Alan (Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2001)
    This thesis describes the development of a chloroplast-localised gene expression system based on the phage T7 RNA polymerase. In order to direct T7 RNAP expression in a leaf-specific manner and to target it to the ...
  • Therapeutic approaches to halting photoreceptor cell death in the retina 

    Tuohy, Gearóid Patrick (Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2001)
    Retinitis pigmentosa (RP) is a group of hereditary retinopathies affecting approximately 1 in 3500 people in the developed world. The disorders are characterised by the early onset of night blindness followed by a ...
  • Comparative analysis of human and mouse acute phase Serum Amyloid A gene expresseion 

    Thorn, Caroline F. (Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2001)
    The Serum Amyloid A (S AA) proteins are a family of highly conserved lipoproteins secreted by the liver. Their production and release is massively induced under conditions of inflammation or infection by pro-inflammatory ...
  • An investigation of the role of caspase-9-interacting proteins in the molecular control of apoptosis 

    Adrain, Colin (Trinity College (Dublin, Ireland). Department of Genetics, 2001)
    Apoptosis is an important homeostatic mechanism that multicellular organisms utilize to delete cells during development and on an ongoing basis in the adult. At the molecular level, this requires the activation of a family ...
  • Evolution of vertebrate genome organisation 

    McLysaght, Aoife (Trinity College (Dublin, Ireland). Department of Genetics, 2002)
    The increasing availability of genomic sequences from different vertebrate organisms affords molecular biologists the opportunity to thoroughly investigate phenomena that were only hinted at by more sparse data. The work ...
  • A bioinformatics approach to (intra-) genome comparisons 

    Hokamp, Karsten (Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2002)
    The analysis of large volumes of genomic data generates special computational needs. A Beowulf-type computer cluster was set up for high-performance computing. Improvements over existing tools for the efficient ...
  • On the role of caspase-recruitment domain proteins in apoptosis and NFkB activation 

    Bouchier-Hayes, Lisa (Trinity College (Dublin, Ireland). Department of Genetics, 2002)
    Apoptosis and NFkB activation are two physiological processes that are essential for host mediated response to cellular injury. Apoptosis is a mechanism that removes damaged or unwanted cells. NFkB is a transcription factor ...
  • Transformation and marker gene removal strategies for the plastid genome of Brassica napus 

    Coyne, Seamus (Trinity College (Dublin, Ireland). Department of Genetics, 2002)
    Despite the fact that the first transplastomic higher plant was produced more than a decade ago, transformation of the plastid genome and the regeneration of homoplasmic, fertile plants has so far been achieved in only 2 ...
  • The development of gene therapy techniques and animal models for Retinitis Pigmentosa and towards the identification of a novel RP-causing gene in a family of Irish origin 

    Allman, Denis (Trinity College (Dublin, Ireland). Department of Genetics, 2003)
    The work presented in this thesis pertains to several different stages in the preclinical development of therapeutics for inherited retinal disease. Chapter two addresses the difficult challenge of delivery of therapeutics ...
  • Evolution of the genomes of two nematodes in the genus Caenorhabditis 

    Coghlan, Avril (Trinity College (Dublin, Ireland). Department of Genetics, 2004)
    The soil-dwelling nematode Caenorhabditis elegans has been intensively studied as a model organism for the last 40 years. It was the first animal for which we had a complete description of development, anatomy, a neural ...
  • The monocyte protein C pathway : implications in human diseases 

    Balding, Joanna (Trinity College (Dublin, Ireland). Department of Genetics, 2004)
    The protein C (PC) pathway provides an important link between the coagulation, fibrinolytic, and inflammatory pathways. PC/activated protein C (APC) is one o f very few therapies shown to effectively reduce the morbidity ...
  • Comparative genomics in yeasts 

    Wong, Simon (Trinity College (Dublin, Ireland). Department of Genetics, 2004)
    Comparative genomics allows us to delve into the fundamental differences among species that form the basis of biodiversity, as well as the preservative forces of natural selection that have left many things unchanged. It ...
  • Cloning and functional characterisation of genes involved in cell death and cell survival 

    Conroy, Helen (Trinity College (Dublin, Ireland). Department of Genetics, 2004)
    During development and as a result of infection or injury, individual cells of multicellular organisms are required to mount appropriate survival or death responses. Two main signalling pathways are responsible for these ...
  • On the molecular genetics of hereditary degenerative retinopathies 

    Aherne, Aileen Mary (Trinity College (Dublin, Ireland). Department of Genetics, 2004)
    The central aim of this thesis was the elucidation of the underlying molecular pathologies of inherited diseases of the retina. The main focus of study concentrates on the molecular genetics and disease mechanisms in ...
  • Characterization of Arabidopsis homologs of the Drosophila SET domain gene Su(var)3-9 

    Casas-Mollano, Juan Armando (Trinity College (Dublin, Ireland). Department of Genetics, 2004)
    SET domain-containing proteins encoded by the Drosophila gene Su(var)3-9 and its human homologue, SUV39H1, are major regulators of heterochromatin formation. The SET domains of these proteins carry histone methyltransferase ...
  • Genetic investigation of Irish ancestry and surname history 

    McEvoy, Brian Patrick (Trinity College (Dublin, Ireland). Department of Genetics, 2005)
    Several genetic systems were employed in this study to investigate Ireland’s pre-history and history. Initially Irish origins were examined using mtDNA sequence variation in 200 new samples coupled with an extensive novel ...
  • Functional characterisation of Arabidopsis genes encoding members of the AP2/ERF transcription factor family 

    Brennan, Sínead (Trinity College (Dublin, Ireland). Department of Genetics, 2005)
    The EU Framework 5 REGIA (Regulatory Gene Initiative in Arabidopsis) Consortium, comprising 29 laboratories, was established to investigate transcription factor gene function in Arabidopsis. As part of the REGIA project, ...
  • Characterization of two flowering gene homologues from Lolium perenne 

    Hayes, James (Trinity College (Dublin, Ireland). Department of Genetics, 2005)
    Lolium perenne (perennial ryegrass) is a primary source of fodder for grazing cattle and is therefore of significant agricultural and economic importance. Understanding the flowering process in this species may help to ...
  • Y chromosomes and Irish phylogeography 

    Moore, Laoise Teresa (Trinity College (Dublin, Ireland). Department of Genetics, 2005)
    A High-Resolution Y Chromosome Survey of Ireland. In order to investigate the origins of the Irish population and to describe the population genetic events that have shaped the extant Irish gene pool, Y chromosome genetic ...