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  • Evolution of vertebrate genome organisation 

    McLysaght, Aoife (Trinity College (Dublin, Ireland). Department of Genetics, 2002)
    The increasing availability of genomic sequences from different vertebrate organisms affords molecular biologists the opportunity to thoroughly investigate phenomena that were only hinted at by more sparse data. The work ...
  • Genetic investigation of Irish ancestry and surname history 

    McEvoy, Brian Patrick (Trinity College (Dublin, Ireland). Department of Genetics, 2005)
    Several genetic systems were employed in this study to investigate Ireland’s pre-history and history. Initially Irish origins were examined using mtDNA sequence variation in 200 new samples coupled with an extensive novel ...
  • Different patterns of gain and loss in genomic evolution 

    González Knowles, David (Trinity College (Dublin, Ireland). Department of Genetics, 2008)
    Evolutionary forces may act on the genome at different levels, from the change of single nucleotides to the duplication or rearrangement of whole chromosomes. Some of these evolutionary processes can be responsible for ...
  • Explorations of miRNA expression in the mammalian retina 

    Loscher, Carol Jane (Trinity College (Dublin, Ireland). Department of Genetics, 2009)
    MicroRNAs (miRs) are an abundant class of non-coding RNAs which, for the most part were undiscovered until early this decade (Lagos-Quintana et al. 2001; Lee et al. 2001). Mature miR transcripts are small (~22 nucleotides) ...
  • Comparative analysis of poxvirus genome evolution 

    Bratke, Kirsten (Trinity College (Dublin, Ireland). Department of Genetics, 2010)
    In this thesis I examine the molecular evolution of poxviruses using various comparative genomics approaches. Poxviruses are large DNA viruses that infect vertebrates and insects. Understanding the evolutionary processes ...
  • Function and evolution of genes in the human protein interaction network 

    Pérez-Bercoff, Åsa (Trinity College (Dublin, Ireland). Department of Genetics, 2012)
    The research conducted for this thesis aims to elucidate how the human protein interaction network has evolved, and how protein interactions influence the spatial organisation of the metabolic network. The thesis presents ...
  • The Chromodomain Helicase DNA binding protein CHD5 is required for neuronal differentiation and repression of non neuronal genes 

    Egan, Chris M. (Trinity College (Dublin, Ireland). Department of Genetics, 2012)
    The candidate tumour suppressor gene chromodomain, helicase DNA-binding protein 5 (CHD5) is frequently deleted in neuroblastoma. However, little is known about the role of the CHD5 protein during normal development or its ...
  • The genetics of amyotrophic lateral sclerosis 

    Kenna, Kevin (Trinity College (Dublin, Ireland). Department of Genetics, 2013)
    Amyotrophic lateral sclerosis, commonly referred to as motor neuron disease or simply ALS, is a neurological disorder which involves the degeneration of upper and lower motor neurons. The disease is associated with a ...
  • The role of Polycomb Repressive Complex 2 associated proteins in mediating complex recruitment 

    Brien, Gerard L. (Trinity College (Dublin, Ireland). Department of Genetics, 2013)
    All multi-cellular organisms are constructed from a myriad of distinct cell types, each performing specialized functions. With very few exceptions all cell types contain the same genetic information encoded in the genome. ...
  • On the development of molecular approaches to therapy for retinitis pigmentosa 

    Nguyen, Anh Thi Hong (Trinity College (Dublin, Ireland). Department of Genetics, 2013)
    Endothelial cells lining the microvasculature of the retina have highly evolved “tight junctions” reducing the space between adjacent cells to form a selective and highly regulatable barrier called the inner blood-retina ...
  • Transcriptional regulation by the ubiquitin system in model plant Arabidopsis thaliana 

    Hanczaryk, Katarzyna (Trinity College (Dublin, Ireland). Department of Genetics, 2014)
    In eukaryotes, the ubiquitin (Ub) system controls protein stability and regulates many developmental and physiological processes, in part through the regulation of transcription. Recent data show that some components of ...
  • Investigation of the immunophilin interactome of malarial parasites 

    Leneghan, Darren (Trinity College (Dublin, Ireland). Department of Genetics, 2014)
    Malaria presents a significant global challenge in both human and economic terms. Approximately 40% of the population of the planet are at risk of contracting malaria, leading to an estimated 225 million cases and ...
  • Examination of transcriptional regulation and functional roles of axon guidance receptors in Drosophila dorsal vessel formation 

    Asadzadeh Tabrizi, Jamshid (Trinity College (Dublin, Ireland). Department of Genetics, 2014)
    Early steps of cardiogenesis in vertebrates and invertebrates are similar in that in both systems, bilateral rows of cardiac progenitors migrate towards a point where the two rows meet and make a tubular structure. As with ...
  • Genetic diagnosis and treatment of inherited retinopathies 

    Carrigan, Matthew (Trinity College (Dublin, Ireland). Department of Genetics, 2014)
    The first goal of this PhD was to improve and optimize a gene therapy based on the yeast protein Ndi 1 for Leber's Hereditary Optic Neuropathy (LHON), a mitochondrially-inherited retinal disorder. LHON is an incompletely ...
  • Modulation of the blood-brain barrier for therapeutic benefit 

    Hanrahan, Finnian (Trinity College (Dublin, Ireland). Department of Genetics, 2014)
    To date this lab has carried out novel work in the area of low-molecular weight (<1 kDa) drug delivery to the retina (Campbell, Nguyen et al. 2009; Tam, Kiang et al. 2010). This work was carried by suppression of claudin-5 ...
  • Modulating oxidative stress in the retina using gene therapy as a potential treatment for inherited retinopathies 

    O'Dwyer, Gareth (Trinity College (Dublin, Ireland). Department of Genetics, 2014)
    The focus of this thesis was the exploration of genetic modulators of oxidative stress in transgenic mouse models of Retinitis Pigmentosa (RP). This disease can be inherited both dominantly and recessively and can be either ...
  • The interplay between cell death and inflammation 

    Henry, Conor Maurice (Trinity College (Dublin, Ireland). Department of Genetics, 2015)
    The connection between cell death and inflammation is an ancient one, first documented in the first century AD by the roman physician Galen. Cell death, as a consequence of tissue injury or infection, is a potent and ...
  • The role of Bcl-2 family in mitochondrial homeostasis 

    Carroll, Richard (Trinity College (Dublin, Ireland). Department of Genetics, 2015)
    Mitochondria are required by cells to generate ATP in order to meet their energy requirements. The electron transport chain, within the mitochondria, pumps protons into the intermembrane space generating an electrochemical ...
  • MicroRNA regulation of the bovine alveolar macrophage response to Mycobacterium bovis 

    Vegh, Peter (Trinity College (Dublin, Ireland). Department of Genetics, 2015)
    Bovine tuberculosis is one of the most economically significant infectious diseases of cattle in Ireland and globally, resulting in economic losses of approximately €2 billion annually. The causative agent is Mycobacterium ...
  • Sterile inflammation and age-related macular degeneration 

    Ozaki, Ema (Trinity College (Dublin, Ireland). Department of Genetics, 2015)
    Age-related macular degeneration (AMD) is the leading cause of legal blindness in elderly individuals in the developed world, estimated to affect 196 million people worldwide by 2020 (Wong et ai, 2014). AMD primarily affects ...