RSS 1.0Genetics (Theses and Dissertations)
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The genetics of amyotrophic lateral sclerosis
(Trinity College (Dublin, Ireland). Department of Genetics, 2013)Amyotrophic lateral sclerosis, commonly referred to as motor neuron disease or simply ALS, is a neurological disorder which involves the degeneration of upper and lower motor neurons. The disease is associated with a ... -
The interplay between cell death and inflammation
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)The connection between cell death and inflammation is an ancient one, first documented in the first century AD by the roman physician Galen. Cell death, as a consequence of tissue injury or infection, is a potent and ... -
The Chromodomain Helicase DNA binding protein CHD5 is required for neuronal differentiation and repression of non neuronal genes
(Trinity College (Dublin, Ireland). Department of Genetics, 2012)The candidate tumour suppressor gene chromodomain, helicase DNA-binding protein 5 (CHD5) is frequently deleted in neuroblastoma. However, little is known about the role of the CHD5 protein during normal development or its ... -
The role of Bcl-2 family in mitochondrial homeostasis
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)Mitochondria are required by cells to generate ATP in order to meet their energy requirements. The electron transport chain, within the mitochondria, pumps protons into the intermembrane space generating an electrochemical ... -
Genetic diagnosis and treatment of inherited retinopathies
(Trinity College (Dublin, Ireland). Department of Genetics, 2014)The first goal of this PhD was to improve and optimize a gene therapy based on the yeast protein Ndi 1 for Leber's Hereditary Optic Neuropathy (LHON), a mitochondrially-inherited retinal disorder. LHON is an incompletely ...
