RSS 1.0Genetics (Theses and Dissertations)
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A new family of vertebrate-specific Polycombs encoded by the Lcor/Lcorl genes balance PRC2 subtype activities
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)The Polycomb Repressive Complex 2 (PRC2) is composed of the core subunits SUZ12, EED, RBBP4/7 and EZH1/2, which together are responsible for all di- and tri- methylation of lysine 27 on Histone H3 (H3K27me2/3). In addition, ... -
A Genomic Compendium of an Island: Documenting Continuity and Change across Irish Human Prehistory
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)This thesis provides an initial demographic scaffold for Irish prehistory based on the palaeogenomic analysis of 93 ancient individuals from all major periods of the island's human occupation, sequenced to a median of 1X ... -
The Multilayered Prehistory of Wild Aurochs and Domestic Cattle
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)This thesis explores 122 ancient genomes of domestic cattle and wild aurochs to investigate past population events such as domestication and admixture. Population genomics of ancient taurine domestics from the ancient Near ... -
The role of death receptors in ER stress and Inflamation
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Cell death induced in response to ER stress, particularly in response to classical ER stress-inducing agents thapsigargin, brefeldin A and tunicamycin, has been shown to be dependent on the ER stress-dependent upregulation ... -
Herding Ancient Domesticates: From Bones to Genomes
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)This thesis demonstrates the power of the analysis of ancient domesticate genomes of cattle and sheep in order to analyse past population dynamics of the two species. In total 113 whole genomes and 127 mitogenomes of wild ...
