RSS 1.0Genetics (Theses and Dissertations)
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A molecular genetic investigation of Irish origins
(Trinity College (Dublin, Ireland). Department of Genetics, 2000)Three hundred and ninety-four male DNA samples, from Ireland, Turkey and Togo, were genotyped for 5 X chromosome simple tandem repeat (STR) loci. Six Y chromosome STR loci and 8 Y chromosome unique event polymorphisms were ... -
Testing the hypothesis of genome duplications in vertebrates
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2000)The hypothesis that the human genome has undergone at least two rounds of genome duplication has become widely accepted, but has never been rigorously tested. In this study, several map-based inter- and intra-species ... -
Gene order evolution and genomic analyses of the model eukaryote, Saccharomyces cerevisiae, and other yeast species
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2000)The complete genome sequence of the yeast Saccharomyces cerevisiae can be used to form a clearer picture of the evolution of the diverse species of yeast and to construct a model of eukaryote genome evolution. In this study ... -
Family-based molecular genetic studies in bipolar affective disorder
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)This thesis covers gene mapping experiments applied to bipolar affective disorder (BPD), a severe recurrent psychiatric condition with a lifetime prevalence of 1-2%, and a substantial familial component. The study sample ... -
Genome sequencing and functional genomics in Bacillus subtilis : the expression and roles of the superoxide dismutases and NADH dehydrogenases
(Trinity College (Dublin, Ireland). Department of Genetics, 2002)The work in this thesis spans genome sequencing of Bacillus subtilis, functional analysis of genes of unknown function and more detailed characterisation of the function and regulation of specific genes. Approximately 0.7% ...
