Recent Submissions

  • Understanding the role of accessory components in regulation of the Polycomb Repressive Complex 2 in mESCs and cancer 

    Mucha, Marlena Klaudia (Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)
    Polycomb Repressive Complex 2 is a chromatin regulatory complex composed of core subunits EZH1/2, EED, SUZ12 and RBBP4/7, around which several accessory components assemble in a mutually exclusive manner to form structurally ...
  • A characterisation of gene duplicability: its determining factors and impact on duplicate evolution 

    Vance, Zoe (Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)
    Duplication, either through whole genome duplication or small-scale duplication, is a critical process in evolution. The duplication of genetic material provides ample opportunity for adaptation and innovation through the ...
  • Exploring the functions of PRC2 in development and congenital disorders 

    Deevy, Orla (Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)
    Polycomb group (PcG) proteins are key chromatin-based repressors of gene expression that play important roles in lineage-specification and cellular memory. PcG proteins assemble into multi-subunit complexes, termed Polycomb ...
  • Development of gene therapies for retinal degenerations 

    Shortall, Ciara (Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2021)
    The studies described in this thesis explore potential gene therapies for retinal degenerative diseases using adeno-associated virus (AAV) vectors for gene delivery. Inherited retinal degenerations (IRDs) are a leading ...
  • Novel therapeutic approaches for open-angle glaucoma 

    Kelly, Ruth (Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2021)
    Glaucoma is the leading cause of blindness worldwide after cataracts and it is estimated that the global prevalence of glaucoma will increase to 111.8 million by 2040 (1, 2). Primary open-angle glaucoma (POAG) is characterized ...

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