RSS 1.0Genetics (Theses and Dissertations)
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Optimisation of therapies for inherited retinal and mitochondrial diseases
Inherited retinal degenerations (IRDs) are the most frequent cause of vision loss in people of working age. They have highly varied causes and pathophysiologies, and are typically incurable. Gene therapy has emerged as a ... -
The blood-brain barrier in neuropsychiatric disorders
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Schizophrenia is a severe and disabling mental disorder that affects approximately 1% of the population. Such is the heterogeneous nature of the disease that genetic, neurobiological and environmental factors all contribute ... -
Targeting the tight-junctions of the conventional outflow pathway in primary open-angle glaucoma.
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Primary open-angle glaucoma (POAG) is one of the leading causes of blindness worldwide, affecting an estimated 44.1 million people (Tham et al. 2014). POAG is characterised by elevated intraocular pressure (IOP) due to ... -
Investigation of the PhoPR two-component signal transduction system in Bacillus subtilis, Staphylococcus aureus and Staphylococcus epidermidis
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Investigation of the PhoPR two-component signal transduction system in Bacillus subtilis, Staphylococcus aureus and Staphylococcus epidermidis. Michael Prunty The PhoPR two-component signal transduction system (TCS) ... -
Tight junctions of blood-brain barrier in Alzheimer's disease
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)Located along the brain endothelium, the blood-brain barrier (BBB) is essential for regulating the exchange of ions and macromolecules between the blood circulation and neural tissue and restricting brain entry of potentially ...
