Recent Submissions

  • Modulation of the blood-brain barrier for therapeutic benefit 

    Hanrahan, Finnian (Trinity College (Dublin, Ireland). Department of Genetics, 2014)
    To date this lab has carried out novel work in the area of low-molecular weight (<1 kDa) drug delivery to the retina (Campbell, Nguyen et al. 2009; Tam, Kiang et al. 2010). This work was carried by suppression of claudin-5 ...
  • Transcriptional regulation by the ubiquitin system in model plant Arabidopsis thaliana 

    Hanczaryk, Katarzyna (Trinity College (Dublin, Ireland). Department of Genetics, 2014)
    In eukaryotes, the ubiquitin (Ub) system controls protein stability and regulates many developmental and physiological processes, in part through the regulation of transcription. Recent data show that some components of ...
  • Explorations of miRNA expression in the mammalian retina 

    Loscher, Carol Jane (Trinity College (Dublin, Ireland). Department of Genetics, 2009)
    MicroRNAs (miRs) are an abundant class of non-coding RNAs which, for the most part were undiscovered until early this decade (Lagos-Quintana et al. 2001; Lee et al. 2001). Mature miR transcripts are small (~22 nucleotides) ...
  • Function and evolution of genes in the human protein interaction network 

    Pérez-Bercoff, Åsa (Trinity College (Dublin, Ireland). Department of Genetics, 2012)
    The research conducted for this thesis aims to elucidate how the human protein interaction network has evolved, and how protein interactions influence the spatial organisation of the metabolic network. The thesis presents ...
  • Evolution of vertebrate genome organisation 

    McLysaght, Aoife (Trinity College (Dublin, Ireland). Department of Genetics, 2002)
    The increasing availability of genomic sequences from different vertebrate organisms affords molecular biologists the opportunity to thoroughly investigate phenomena that were only hinted at by more sparse data. The work ...

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