RSS 1.0Genetics (Theses and Dissertations)
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Comparing Pathways for Retinal and Neuronal Degeneration in Drosophila melanogaster
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)Past work to understand the mechanisms of cellular degeneration has either focused on retinal degeneration or neurodegeneration. These studies have revealed that the integrated stress response (ISR) and RNA binding proteins ... -
Retrieval of DNA from ancient material and the demography of the extinct aurochs
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)Ancient DNA has revolutionised our understanding of animal genomics by providing direct evidence of the demography of ancient wild populations and unravelling the complex domestication process with time-stamped precision. ... -
Investigation of transcriptome changes during flower development using third-generation sequencing and inducible gene perturbation approaches
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)Over the last 30 years, flower development has been intensively studied us- ing a wide range of genetic and molecular methods. Much of this work was guided by the ABC model of floral organ identity specification, which ... -
The inner blood retinal barrier in ocular disease and circadian regulation: its role in age related macular degeneration development and other neuro-ophthalmology disorders
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)Age related macular degeneration (AMD) is one of the most common causes of irreversible sight loss worldwide. The initial pathophysiological events that occur in AMD are poorly understood, with most research focusing on ... -
Investigating Polycomb group proteins as genetic dependencies in H3-K27M mutant paediatric glioma.
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)Polycomb group proteins play an important role in the maintenance of cellular identity by contributing to transcriptional repression through the regulation of chromatin structure. These proteins form two main multimeric ...
