RSS 1.0Genetics (Theses and Dissertations)
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Ancient Goat Genomics: Structure, Selection, and Admixture
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2019)The wild bezoar Capra aegagrus was brought under human control c. 8,000 BC, leading to the domestic goat Capra hircus. This livestock species remains in use 10,000 years later, and is of particular importance to communities ... -
Understanding the diverse roles of polycomb-like proteins in the regulation of chromatin and transcriptional landscapes
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2019)The Polycomb repressive complex 2 (PRC2) is a multiprotein chromatin modifying complex that is essential for vertebrate development and frequently deregulated in cancer. In higher eukaryotes, PRC2 is responsible for all ... -
Blood-retina barrier regulation and sterile inflammation in retinal homeostasis and disease
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2019)Age-related macular degeneration (AMD) is the leading cause of central vision loss and blindness in the elderly. It is caused by a progressive loss of photoreceptors in the macula, thought to occur secondary to the damage ... -
Alternative routes to optimal expression levels: Evolutionary evidence for competitive RNAs and dosage compensation by gene duplication
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2019)Expression evolution and dosage constraints are important factors shaping genomic content and innovation. It has become increasingly clear that non-coding RNAs perform various regulatory functions in different cellular ... -
Therapeutic approaches to halting photoreceptor cell death in the retina
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2001)Retinitis pigmentosa (RP) is a group of hereditary retinopathies affecting approximately 1 in 3500 people in the developed world. The disorders are characterised by the early onset of night blindness followed by a progressive ...
