RSS 1.0Genetics (Theses and Dissertations)
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A novel gene-based therapy for galaucoma:from discovery to preclinical development
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Introduction: Glaucoma is a multifactorial condition that will often result in complete bilateral blindness if untreated. Elevated intraocular pressure (IOP) is both a major risk factor and indicator of disease. IOP is ... -
Complex evolutionary dynamics in simple genomes: the paradoxical survival of intracellular symbiotic bacteria
(Trinity College (Dublin, Ireland). Department of Genetics, 2009)Symbiosis is one of the ways in which nature has been able to generate biological innovation by fusing two organisms with different complexities. Because of these differing complexities, many problems for both organisms ... -
The genetics of Mycobacterium bovis infection in Irish cattle
(Trinity College (Dublin, Ireland). Department of Genetics, 2016)Infection of livestock with Mycobacterium bovis, is the causing agent of bovine tuberculosis and is of major economic and health concern globally, with the cost of livestock loss estimated at €2 billion globally. In developed ... -
Interpretation and improvement of the current genetic epidemiology methodology for schizophrenia
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Recent technological advancements have allowed for the development of new methodologies in the investigation of the genetic epidemiology of schizophrenia. Two of the most prominent methods in that field are the Polygenic ... -
Genetic analyses of thalamocortical axon guidance and subpallial development
(Trinity College (Dublin, Ireland). Department of Genetics, 2016)Normal brain functioning in mammals depends on the establishment of specific, finely-organised neural networks connecting distant regions during development. In particular, sensory stimuli processing is supported by ...
