RSS 1.0Genetics (Theses and Dissertations)
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Ancient Genomics and Human Health
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)Studies of ancient DNA over the last decade have been pivotal in answering archaeological, evolutionary and ecological questions. More recently, this data has also been used in the analysis of human health in the past, in ... -
Investigating the roles of SMARCA4 and EP300 in synovial sarcoma
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)Synovial sarcoma is a rare and aggressive cancer that accounts for approximately 10% of all soft tissue sarcomas diagnosed annually. This malignancy is caused by a characteristic fusion protein known as SS18- SSX and is ... -
Using Micro-Synteny for Phylogenetic Inference and Analysis
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)Phylogenetics is the study of the evolutionary relationships and history of groups of organisms. Over the past twenty years, the burgeoning number of sequenced genomes has revolutionised the field of phylogenetics taking ... -
Modulation of mitochondrial function as a therapeutic strategy for Stargardt disease and an exploration of the genetic architecture of Stargardt disease in Ireland
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)Inherited retinal degenerations (IRDs) are an extremely heterogeneous group of disorders, together representing the most common cause for vision loss in young people. An estimated 5.5 million people globally are living ... -
Gene duplication in the coral genus Acropora
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)Whole Genome Duplications (WGD) pose major evolutionary events, giving rise to increased gene diversity. They have often been associated with major changes e.g. mass extinctions. The coral genus Acropora is a reef-building ...
