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  • Analysis of stage-specific gene perturbations and characterisation of two novel F-box genes during flower development in Arabidopsis thaliana 

    THOMSON, BENNETT (Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)
    The model plant Arabidopsis thaliana has been used for past three decades to study the genetic and molecular processes underlying floral organogenesis. Flowers of this small plant consist of four concentric whorls, containing ...
  • The blood-brain barrier in neuropsychiatric disorders 

    GREENE, CHRIS (Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)
    Schizophrenia is a severe and disabling mental disorder that affects approximately 1% of the population. Such is the heterogeneous nature of the disease that genetic, neurobiological and environmental factors all contribute ...
  • Comparative analysis of poxvirus genome evolution 

    Bratke, Kirsten (Trinity College (Dublin, Ireland). Department of Genetics, 2010)
    In this thesis I examine the molecular evolution of poxviruses using various comparative genomics approaches. Poxviruses are large DNA viruses that infect vertebrates and insects. Understanding the evolutionary processes ...
  • Control of floral meristem activity in the model plant Arabidopsis thaliana 

    KWASNIEWSKA, KAMILA (Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2017)
    Over the past 30 years, the flower development has been one of the main model to study the genetic control of organogenesis in higher plants. The work on Arabidopsis thaliana has led to the proposal of the ABC model of ...
  • Different patterns of gain and loss in genomic evolution 

    González Knowles, David (Trinity College (Dublin, Ireland). Department of Genetics, 2008)
    Evolutionary forces may act on the genome at different levels, from the change of single nucleotides to the duplication or rearrangement of whole chromosomes. Some of these evolutionary processes can be responsible for ...
  • Evolution of vertebrate genome organisation 

    McLysaght, Aoife (Trinity College (Dublin, Ireland). Department of Genetics, 2002)
    The increasing availability of genomic sequences from different vertebrate organisms affords molecular biologists the opportunity to thoroughly investigate phenomena that were only hinted at by more sparse data. The work ...
  • Examination of transcriptional regulation and functional roles of axon guidance receptors in Drosophila dorsal vessel formation 

    Asadzadeh Tabrizi, Jamshid (Trinity College (Dublin, Ireland). Department of Genetics, 2014)
    Early steps of cardiogenesis in vertebrates and invertebrates are similar in that in both systems, bilateral rows of cardiac progenitors migrate towards a point where the two rows meet and make a tubular structure. As with ...
  • Explorations of miRNA expression in the mammalian retina 

    Loscher, Carol Jane (Trinity College (Dublin, Ireland). Department of Genetics, 2009)
    MicroRNAs (miRs) are an abundant class of non-coding RNAs which, for the most part were undiscovered until early this decade (Lagos-Quintana et al. 2001; Lee et al. 2001). Mature miR transcripts are small (~22 nucleotides) ...
  • Function and evolution of genes in the human protein interaction network 

    Pérez-Bercoff, Åsa (Trinity College (Dublin, Ireland). Department of Genetics, 2012)
    The research conducted for this thesis aims to elucidate how the human protein interaction network has evolved, and how protein interactions influence the spatial organisation of the metabolic network. The thesis presents ...
  • Genetic diagnosis and treatment of inherited retinopathies 

    Carrigan, Matthew (Trinity College (Dublin, Ireland). Department of Genetics, 2014)
    The first goal of this PhD was to improve and optimize a gene therapy based on the yeast protein Ndi 1 for Leber's Hereditary Optic Neuropathy (LHON), a mitochondrially-inherited retinal disorder. LHON is an incompletely ...
  • Genetic investigation of Irish ancestry and surname history 

    McEvoy, Brian Patrick (Trinity College (Dublin, Ireland). Department of Genetics, 2005)
    Several genetic systems were employed in this study to investigate Ireland’s pre-history and history. Initially Irish origins were examined using mtDNA sequence variation in 200 new samples coupled with an extensive novel ...
  • Genetics of calving performance 

    Purfield, Deirdre Christina (Trinity College (Dublin, Ireland). Department of Genetics, 2015)
    Calving performance is a significant contributor to the profitability of cattle production systems whilst also becoming an increasingly important welfare issue in recent years. Calving performance includes both dystocia ...
  • A Genomic Compendium of an Island: Documenting Continuity and Change across Irish Human Prehistory 

    CASSIDY, LARA (Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)
    This thesis provides an initial demographic scaffold for Irish prehistory based on the palaeogenomic analysis of 93 ancient individuals from all major periods of the island's human occupation, sequenced to a median of 1X ...
  • Herding Ancient Domesticates: From Bones to Genomes 

    MULLIN, VICTORIA ELIZABETH (Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)
    This thesis demonstrates the power of the analysis of ancient domesticate genomes of cattle and sheep in order to analyse past population dynamics of the two species. In total 113 whole genomes and 127 mitogenomes of wild ...
  • Inflammatory consequences of divergent cell death signals 

    Kearney, Conor J. (Trinity College (Dublin, Ireland). Department of Genetics, 2015)
    Tumor Necrosis Factor (TNF) is an apical cytokine that drives inflammation through triggering the synthesis and secretion of multiple downstream pro-inflammatory cytokines and chemokines. Generally, TNF stimulation does ...
  • Investigation of the immunophilin interactome of malarial parasites 

    Leneghan, Darren (Trinity College (Dublin, Ireland). Department of Genetics, 2014)
    Malaria presents a significant global challenge in both human and economic terms. Approximately 40% of the population of the planet are at risk of contracting malaria, leading to an estimated 225 million cases and ...
  • Investigation of the PhoPR two-component signal transduction system in Bacillus subtilis, Staphylococcus aureus and Staphylococcus epidermidis 

    PRUNTY, MICHAEL (Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)
    Investigation of the PhoPR two-component signal transduction system in Bacillus subtilis, Staphylococcus aureus and Staphylococcus epidermidis. Michael Prunty The PhoPR two-component signal transduction system (TCS) ...
  • MicroRNA regulation of the bovine alveolar macrophage response to Mycobacterium bovis 

    Vegh, Peter (Trinity College (Dublin, Ireland). Department of Genetics, 2015)
    Bovine tuberculosis is one of the most economically significant infectious diseases of cattle in Ireland and globally, resulting in economic losses of approximately €2 billion annually. The causative agent is Mycobacterium ...
  • Modulating oxidative stress in the retina using gene therapy as a potential treatment for inherited retinopathies 

    O'Dwyer, Gareth (Trinity College (Dublin, Ireland). Department of Genetics, 2014)
    The focus of this thesis was the exploration of genetic modulators of oxidative stress in transgenic mouse models of Retinitis Pigmentosa (RP). This disease can be inherited both dominantly and recessively and can be either ...
  • Modulation of the blood-brain barrier for therapeutic benefit 

    Hanrahan, Finnian (Trinity College (Dublin, Ireland). Department of Genetics, 2014)
    To date this lab has carried out novel work in the area of low-molecular weight (<1 kDa) drug delivery to the retina (Campbell, Nguyen et al. 2009; Tam, Kiang et al. 2010). This work was carried by suppression of claudin-5 ...