Identification and characterisation of a novel Polycomb Repressive Complex 2 associated protein that is an alternatively spliced product of the LCOR gene locus
Citation:
Emilia Jerman, 'Identification and characterisation of a novel Polycomb Repressive Complex 2 associated protein that is an alternatively spliced product of the LCOR gene locus', [thesis], Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2015, pp 158Download Item:
Jerman TCD THESIS 10942 Identification and.pdf (PDF) 58.32Mb
Abstract:
Polycombs are evolutionary conserved epigenetic regulators crucial for
specification of cell types during development. They assemble in multiprotein
complexes to modify amino terminal tails of histone H3 at lysine 27 to regulate the
expression of underlying genes. PRC2 mediates repression by catalysing trimethylation
of histone H3 at lysine 27 (H3K27me) at the promoters of master
transcriptional regulators, such as HOX and cell cycle and proliferation regulating
genes. Recently, it emerged that PRC2 also mediates the mono-and dimethylation
of H3K27 and that these histone marks are associated with gene
activation and enhancer silencing, respectively.
Author: Jerman, Emilia
Advisor:
Bracken, AdrianQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Genetics and MicrobiologyNote:
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