| dc.contributor.advisor | O'Neill, Luke | |
| dc.contributor.author | Jefferies, Caroline | |
| dc.date.accessioned | 2019-07-25T13:21:29Z | |
| dc.date.available | 2019-07-25T13:21:29Z | |
| dc.date.issued | 2001 | |
| dc.identifier.citation | Caroline Jefferies, 'Involvement of the low molecular weight G protein Rac1 in IL-1 signalling to NFkB activation', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2001, pp 238 | |
| dc.identifier.other | THESIS 6156 | |
| dc.identifier.uri | http://hdl.handle.net/2262/88894 | |
| dc.description.abstract | The involvement of the low molecular weight G protein Rac1 in IL-1 signal transduction has been suggested by studies that have demonstrated that a dominant negative mutant of Rac1 can inhibit IL-1-induced activation of both p38 and JNK mitogen activated protein kinase (MAPK) pathways. This prompted the investigation into the role of Rac1 in other IL-1-induced events in T lymphocytes, namely its ability to drive IL-2 expression, using the IL-1 receptor rich murine thymoma cell line EL4.N0B-1. | |
| dc.format | 1 volume | |
| dc.language.iso | en | |
| dc.publisher | Trinity College (Dublin, Ireland). School of Biochemistry and Immunology | |
| dc.relation.isversionof | http://stella.catalogue.tcd.ie/iii/encore/record/C__Rb12464454 | |
| dc.subject | Biochemistry, Ph.D. | |
| dc.subject | Ph.D. Trinity College Dublin | |
| dc.title | Involvement of the low molecular weight G protein Rac1 in IL-1 signalling to NFkB activation | |
| dc.type | thesis | |
| dc.type.supercollection | thesis_dissertations | |
| dc.type.supercollection | refereed_publications | |
| dc.type.qualificationlevel | Doctoral | |
| dc.type.qualificationname | Doctor of Philosophy (Ph.D.) | |
| dc.rights.ecaccessrights | openAccess | |
| dc.format.extentpagination | pp 238 | |
| dc.description.note | TARA (Trinity's Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie | |
