Involvement of the low molecular weight G protein Rac1 in IL-1 signalling to NFkB activation
Citation:
Caroline Jefferies, 'Involvement of the low molecular weight G protein Rac1 in IL-1 signalling to NFkB activation', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2001, pp 238Download Item:
Jefferies TCD THESIS 6156 Involvement of.pdf (PDF) 132.3Mb
Abstract:
The involvement of the low molecular weight G protein Rac1 in IL-1 signal transduction has been suggested by studies that have demonstrated that a dominant negative mutant of Rac1 can inhibit IL-1-induced activation of both p38 and JNK mitogen activated protein kinase (MAPK) pathways. This prompted the investigation into the role of Rac1 in other IL-1-induced events in T lymphocytes, namely its ability to drive IL-2 expression, using the IL-1 receptor rich murine thymoma cell line EL4.N0B-1.
Author: Jefferies, Caroline
Advisor:
O'Neill, LukeQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Biochemistry and ImmunologyNote:
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Biochemistry, Ph.D., Ph.D. Trinity College DublinLicences: