Browsing Biochemistry (Scholarly Publications) by Author "Finlay, David"
Now showing items 1-19 of 19
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Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation
Finlay, David; Jones, Nicholas; Vincent, Emma E.; Cronin, James G.; Panetti, Silvia; Chambers, Megan; Holm, Sean R.; Owens, Sian E.; Francis, Nigel J.; Thornton, Catherine A. (2019)Metabolic pathways that regulate T-cell function show promise as therapeutic targets in diverse diseases. Here, we show that at rest cultured human effector memory and central memory CD4+ T-cells have elevated levels of ... -
Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice
Finlay, David; Gardiner, Clair (2018) -
The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing
Mills, Kingston; Finlay, David (2022)Dendritic cells play a key role in processing and presenting antigens to naïve T cells to prime adaptive immunity. Circadian rhythms are known to regulate many aspects of immunity; however, the role of circadian rhythms ... -
The co-ordination of T cell function by Serine/threonine kinases
Finlay, David (2011)The function of T-lymphocytes during adaptive immune responses is directed by antigen receptors, costimulatory molecules, and cytokines. These extrinsic stimuli are coupled to a network of serine/threonine kinases that ... -
Competition for nutrients; an emerging role in controlling immune responses
Finlay, David; Kedia-Mehta, Nidhi (2019)Changes in cellular metabolism are associated with the activation of diverse immune subsets. These changes are fuelled by nutrients including glucose, amino acids and fatty acids, and are closely linked to immune cell fate ... -
Diverse Immunoregulatory Roles of Oxysterols - The Oxidized Cholesterol Metabolites
Finlay, David (2020)Intermediates of both cholesterol synthesis and cholesterol metabolism can have diverse roles in the control of cellular processes that go beyond the control of cholesterol homeostasis. For example, oxidized forms of ... -
Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation
Finlay, David (2021)Fructose intake has increased substantially throughout the developed world and is associated with obesity, type 2 diabetes and non-alcoholic fatty liver disease. Currently, our understanding of the metabolic and mechanistic ... -
Glucose represses dendritic cell-induced T cell responses
Finlay, David; Murray, James (2017) -
Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element
Finlay, David (2004)Background: Hepatic expression of several gene products involved in glucose metabolism, including phosphoenolpyruvate carboxykinase (PEPCK), glucose-6-phosphatase (G6Pase) and insulin-like growth factor binding protein-1 ... -
Immunometabolism and Natural Killer cell responses
Finlay, David; O'Brien, Katie L. (2019)Natural killer (NK) cells are lymphocytes with important roles in innate and adaptive immune responses to tumours and viral infection. However, in certain chronic diseases, including obesity and cancer, NK cell functional ... -
Metabolic but not transcriptional regulation by PKM2 is important for Natural Killer cell responses
Finlay, David (2020)Natural Killer (NK) cells have an important role in immune responses to viruses and tumours. Integrating changes in signal transduction pathways and cellular metabolism is essential for effective NK cells responses. The ... -
Metabolism, migration and memory in cytotoxic T cells
Finlay, David (2011)The transcriptional and metabolic programmes that control CD8(+) T cells are regulated by a diverse network of serine/threonine kinases. The view has been that the kinases AKT and mammalian target of rapamycin (mTOR) control ... -
Natural Killer cells integrate signals received from tumour interactions and IL2 to induce robust and prolonged anti-tumour and metabolic responses
Finlay, David; Kedia-Mehta, Nidhi; Choi, Chloe; McCrudden, Aisling; Littwitz-Salomon, Elisabeth; Fox, Proinnsias G.; Gardiner, Clair M. (2019)Natural Killer (NK) cells are lymphocytes with an important role in anti-tumour responses. NK cells bridge the innate and adaptive arms of the immune system; they are primed for immediate anti-tumour function but can also ... -
PDK1 regulation of mTOR and Hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells
Finlay, David (2012)mTORC1 (mammalian target of rapamycin complex 1) controls transcriptional programs that determine CD8+ cytolytic T cell (CTL) fate. In some cell systems, mTORC1 couples phosphatidylinositol-3 kinase (PI3K) and Akt to the ... -
Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration.
Finlay, David (2010)The established role for phosphatidylinositol (3,4,5) triphosphate (PI(3,4,5)P3) signaling pathways is to regulate cell metabolism. More recently it has emerged that PI(3,4,5)P3 signaling via mammalian target of rapamycin ... -
Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes
Finlay, David (2009)In normal T cell progenitors, phosphoinositide-dependent kinase l (PDK1)-mediated phosphorylation and activation of protein kinase B (PKB) is essential for the phosphorylation and inactivation of Foxo family transcription ... -
Temporal differences in the dependency on Phosphoinositide dependent kinase 1 distinguish the development of Vα14 iNKT cells, regulatory T cells and conventional T cells
Finlay, David (2010)The present study uses two independent genetic strategies to explore the requirement for Phosphoinositide dependent kinase-1 (PDK1) in the development of mature T cell populations from CD4/CD8 double positive thymocytes. ... -
A temporal switch in the insulin-signalling pathway that regulates hepatic IGF-binding protein-1 gene expression
Finlay, David (2006)Insulin regulation of hepatic gene transcription is a vital component of glucose homeostasis. Understanding the molecular regulationof thisprocess aids the searchfor the defect(s) that promotesinsulin-resistant states, ... -
TGFβ drives NK cell metabolic dysfunction in human metastatic breast cancer
Finlay, David (2021)Background Natural killer (NK) cells provide important immune protection from cancer and are a key requirement for particular immunotherapies. There is accumulating evidence that NK cells become dysfunctional during cancer. ...