Browsing Biochemistry (Scholarly Publications) by Title
Now showing items 1-20 of 536
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2-mercaptoethanol restores the ability of nuclear factor kappa B (NF kappa B) to bind DNA in nuclear extracts from interleukin 1-treated cells incubated with pyrollidine dithiocarbamate (PDTC)
(Portland Press, 1997)The metal chelator and anti-oxidant pyrollidine dithiocarbamate (PDTC) has been used extensively in studies implicating reactive oxygen intermediates in the activation of nuclear factor kappa B (NF kappa B). In agreement ... -
A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling
(2000)Poxviruses employ many strategies to evade and neutralize the host immune response. In this study, we have identified two vaccinia virus ORFs, termed A46R and A52R, that share amino acid sequence similarity with the Toll/IL-1 ... -
Absence of Mitochondrial Uncoupling Protein 1 Affects Apoptosis in Thymocytes, Thymocyte/T-Cell profile and Peripheral T-Cell Number
(Elsevier, 2010)Our laboratory has previously demonstrated the presence of constitutively expressed mitochondrial uncoupling protein 1 in mouse thymocytes. In our endeavours to understand the role of mitochondrial uncoupling protein 1 in ... -
Absence of mitochondrial uncoupling protein 3: Effect on thymus and spleen in the fed and fasted mice
(2011)Mitochondrial uncoupling protein 3 (UCP3) is consituitively expressed in mitochondria from thymus and spleen of mice, and confocal microscopy has been used to visualize UCP3 in situ in mouse thymocytes. UCP3 is present ... -
Activation of biliverdin-IXα reductase by inorganic phosphate and related anions
(2007)The effect of pH on the initial-rate kinetic behaviour of BVR-A (biliverdin-IX? reductase) exhibits an alkaline optimum with NADPH as cofactor, but a neutral optimum with NADH as cofactor. This has been described as dual ... -
Activation of host pattern recognition receptors by viruses
(2010)Viral recognition by the host innate immune system has become an exciting and growing area of research focus in recent years. It is now apparent that multiple pattern recognition receptor (PRR) families, including Toll-like ... -
Activation of human invariant natural killer T cells with a thioglycoside analogue of ?-galactosylceramide
(2011)Activation of CD1d-restricted invariant NKT (iNKT) cells with the glycolipid ?-galactosylceramide (?-GalCer) confers protection against disease in murine models, however, clinical trials in humans have had limited impact. ... -
Activation of mixed glia by A-beta-specific Th1 and Th17 cells and its regulation by Th2 cells
(2010)Microglia are innate immune cells of the CNS, that act as antigen-presenting cells (APC) for antigen-specific T cells and respond to inflammatory stimuli, such as amyloid-beta (A?), resulting in the release of neurotoxic ... -
Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells.
(2014)The anti-diabetic drug metformin regulates T-cell responses to immune activation and is proposed to function by regulating the energy-stress-sensing adenosine-monophosphate-activated protein kinase (AMPK). However, the ... -
Adenylate cycalse toxin of Bordetella pertussis inhibits TLR-induced IRF-1 and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cells
(Society of Leukocyte Biology, 2008)Adenylate cyclase toxin (CyaA) of Bordetella pertussis binds to CD11b/CD18 on macrophages and dendritic cells (DC) and confers virulence to the bacteria by subverting innate immune responses of the host. We have previously ... -
Adenylate cyclase toxin from Bordetella pertussis synergises with lipopolysaccharide to promote innate IL-10 production and enhance the induction of Th2 and regulatory T cells
(American Society for Microbiology, 2004)Adenylate cyclase toxin (CyaA) from Bordetella pertussis can subvert host immune responses allowing bacterial colonization. Here we have examined its adjuvant and immunomodulatory properties and the possible contribution ... -
Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production.
(2012)Invariant natural killer T (iNKT) cells are evolutionarily conserved innate T cells that influence inflammatory responses. We have shown that iNKT cells, previously thought to be rare in humans, were highly enriched in ... -
Advances in immunotherapy for the treatment of glioblastoma.
(2017)Glioblastoma (GBM) is an aggressive brain tumour, associated with extremely poor prognosis and although there have been therapeutic advances, treatment options remain limited. This review focuses on the use of immunotherapy, ... -
Alpha gliadin antibody levels: a serological test for coeliac disease.
(1983)The diagnostic value in coeliac disease of circulating antibodies to casein, crude gliadin, and alpha gliadin was assessed using an adaption of the enzyme linked immunosorbent assay system. alpha Gliadin was the only antigen ... -
Altered Expression of Caspases-4 and -5 during Inflammatory Bowel Disease and Colorectal Cancer - Novel Diagnostic and Therapeutic Potential.
(2015)Caspases are a group of proteolytic enzymes involved in the co-ordination of cellular processes, including cellular homeostasis, inflammation and apoptosis. Altered activity of caspases, particularly caspase-1, has ... -
Altered gastrointestinal immune response in sarcoidosis.
(1988)Because of the possible clinical association between coeliac disease and sarcoidosis, the incidence of humoral sensitivity to dietary proteins was examined in patients with sarcoidosis. Raised concentrations of circulating ...
