The co-ordination of T cell function by Serine/threonine kinases
Citation:Finlay DK, Cantrell DA, The co-ordination of T cell function by Serine/threonine kinases, Cold Spring Harbour Perspectives in Biology, 3, 1, 2011
The Coordination of T-cell Function by Serine:Threonine Kinases.pdf (Published (publisher's copy) - Peer Reviewed) 471.3Kb
The function of T-lymphocytes during adaptive immune responses is directed by antigen receptors, costimulatory molecules, and cytokines. These extrinsic stimuli are coupled to a network of serine/threonine kinases that control the epigenetic, transcriptional, and meta- bolic programs that determine T-cell function. It is increasingly recognized that serine/thre- onine kinases, notably those that are controlled by lipid second messengers such as polyunsaturated diacylglycerols (DAG) and phosphatidylinositol-(3,4,5)-trisphosphate (PIP3), are at the core of T-cell signal transduction. In the present review the object will be to discuss some important examples of how pathways of serine/threonine phosphorylation control molecular functions of proteins and control protein localization to coordinate T-cell function in adaptive immune responses.
Author: Finlay, David
Series/Report no:Cold Spring Harbour Perspectives in Biology
Availability:Full text available
Subject (TCD):Immunology, Inflammation & Infection