RSS 1.0Biochemistry (Scholarly Publications)
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Diverse Immunoregulatory Roles of Oxysterols - The Oxidized Cholesterol Metabolites
(2020)Intermediates of both cholesterol synthesis and cholesterol metabolism can have diverse roles in the control of cellular processes that go beyond the control of cholesterol homeostasis. For example, oxidized forms of ... -
Metabolic but not transcriptional regulation by PKM2 is important for Natural Killer cell responses
(2020)Natural Killer (NK) cells have an important role in immune responses to viruses and tumours. Integrating changes in signal transduction pathways and cellular metabolism is essential for effective NK cells responses. The ... -
Characterizing caspase-1 involvement during esophageal disease progression.
(2020)Barrett’s esophagus (BE) is an inflammatory condition and a neoplastic precursor to esophageal adenocarcinoma (EAC). Inflammasome signaling, which contributes to acute and chronic inflammation, results in caspase-1 activation ... -
Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation
(2020)Histone deacetylase inhibitors (HDACi) have emerged as promising therapeutics for the treatment of neurodegeneration, cancer, and rare disorders. Herein, we report the development of a series of spiroindoline-based HDAC6 ... -
Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity
(2020)A multitude of diverse microorganisms, termed the microbiota, reside in the gut, respi-ratory tract, skin, and genital tract of humans and other animals. Recent advances inmetagenomic sequencing and bioinformatics have ...
