Competition for nutrients; an emerging role in controlling immune responses
Citation:Kedia-Mehta, N. & Finlay, D.K. Competition for nutrients; an emerging role in controlling immune responses, 2019, Nature Communications, 10;1
s41467-019-10015-4(1).pdf (PDF) 1.184Mb
Changes in cellular metabolism are associated with the activation of diverse immune subsets. These changes are fuelled by nutrients including glucose, amino acids and fatty acids, and are closely linked to immune cell fate and function. An emerging concept is that nutrients are not equally available to all immune cells, suggesting that the regulation of nutrient utility through competitive uptake and use is important for controlling immune responses. This review considers immune microenvironments where nutrients become limiting, the signalling alterations caused by insufficient nutrients, and the importance of nutrient availability in the regulation of immune responses.
Science Foundation Ireland (SFI)
Series/Report no:Nature Communications;
Availability:Full text available
Subject (TCD):Immunology, Inflammation & Infection , Immunometabolism , NUTRIENT RESTRICTION , NUTRIENTS , SIGNAL TRANSDUCTION