Immunometabolism and Natural Killer cell responses
Citation:O'Brien, K.L. & Finlay, D.K., Immunometabolism and Natural Killer cell responses, Nature Reviews Immunology, 19, 5, 2019, 282 - 290
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Natural killer (NK) cells are lymphocytes with important roles in innate and adaptive immune responses to tumours and viral infection. However, in certain chronic diseases, including obesity and cancer, NK cell functional responses are impaired. Recently, research has highlighted the importance of NK cell metabolism in facilitating robust NK cell effector functions. This Review describes our current understanding of mouse and human NK cell metabolism and the key signalling pathways that mediate metabolic responses in NK cells. Furthermore, it explores how defects in metabolism can contribute to the generation of dysfunctional NK cells in chronic disease. Finally, the potential for new therapeutic strategies targeting cellular metabolism is discussed.
Science Foundation Ireland (SFI)
Series/Report no:Nature Reviews Immunology;
Availability:Full text available
Keywords:Natural killer cells, Lymphocyte, Immune response, Tumours, Viral infection, Immune cell function, Cellular metabolism