The establishment of hybrid cell lines from human pancreas
Citation:George W. Reid, 'The establishment of hybrid cell lines from human pancreas', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2001, pp 276
Reid TCD THESIS 6107 The establishment.pdf (PDF) 163.1Mb
The need for research into diabetes mellitus is ever increasing. Of specific interest are the mechanisms responsible for glucose-responsive insulin secretion and the autoimmune destruction of pancreatic p-cells. However, assessment of normal pancreatic P cell function at the molecular level continues to be hampered by the heterogeneity and limited yields of viable human experimental material. Pancreatic P cell lines have proven extremely useful in overcoming sonnie of these problems, and thus the potential usefulness of a human pancreatic P cell line has long been recognised. At the onset of this project no functional human P cell line had been established, despite repeated attempts. It is only in the last year that such a cell line has at last been generated. Of all the reported attempts to establish a human P cell line, or a P cell line exhibiting human characteristics, none had employed the strategy of a cell fusion involving normal human P cells.
Author: Reid, George W.
Publisher:Trinity College (Dublin, Ireland). School of Biochemistry and Immunology
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Type of material:thesis
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