Browsing Immunology (Theses and Dissertations) by Title
Now showing items 1-20 of 28
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Analysis of the autoantibody response directed against tissue transglutaminase in coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2006)Coeliac disease is an inflammatory disease of the proximal small intestine caused by wheat gluten ingestion in genetically susceptible individuals. The mucosal pathology in coeliac disease is characterised by villous ... -
Characterisation of gut mucosa in patients with potential coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2007)Coeliac disease is a gluten dependent enteropathy with a high incidence and increased risk of mortality. Diagnosis of coeliac disease is based on a biopsy of small intestine. However, it is now believed that many individuals ... -
Characterisation of mouse strains with spontaneous mutations, leading to epidermal barrier dysfunction and inflammation
(Trinity College (Dublin, Ireland). Department of Immunology, 2013)Atopic dermatitis is a chronic pruritic skin disease, associated with eczematous lesions, epidermal barrier dysfunction, and Immunoglobulin-E-mediated sensitization to food and environmental allergens. The complex ... -
Defiency of natural killer receptor expressing cells in haemophagocytic lymphohistiocytosis
(Trinity College (Dublin, Ireland). Department of Immunology, 2002)Two children, patient A and patient B, were diagnosed on clinical and histological grounds to have haemophagocytic lymphohistiocytosis (HLH) (Henter et al. 1991a; Arico et al. 2001a). Clinical presentation of HLH consists ... -
Design, optimisation and functional relevance of in silico tools for the study of coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2008)Peptide-MHC interaction is a crucial pre-requisite for the recognition of antigen by T cells. It has long been recognised that peptides with a high affinity for MHC molecules are more likely to elicit a pronounced T cell ... -
Effect of nutritional status and nutritional supplementation on clinical, nutritional and immunological outcomes among HIV infected adults in Uganda
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2019) -
Epigenetic targeting of CD1d increases cytolytic activity of invariant natural killer T cells against non-small cell lung cancer cells
(Trinity College (Dublin, Ireland). Department of Immunology, 2016)Lung cancer is the most common form of cancer-related death in the world, accounting for approximately 19.4% of all cancer mortalities. Currently platinum-based therapies are the gold-standard of care for non-small cell ... -
Evolutionary origins and functions of Schistosoma mansoni Pellino
(Trinity College (Dublin, Ireland). Department of Immunology, 2012)The immune system of modern man has innate signalling pathways that arose in ancestral species. This is exemplified by the discovery of the Toll-like receptor (TLR) pathway using free-living model organisms, specifically ... -
Examining the role of lymphocytes in health and in neonatal encephalopathy and the influence of mucosal associated T cells on B cell functions
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2022)Background. Neonatal encephalopathy (NE) is a neurological syndrome in term babies characterised by altered levels of consciousness, seizures, abnormal tone and reflexes, and/or failure to initiate or maintain respiration. ... -
Functional studies on human γδ T cells and their interactions with dendritic cells and B cells
(Trinity College (Dublin, Ireland). Department of Immunology, 2016)γδ T cells are innate T cells that play central roles in protection against microorganisms and cellular stress. There are three main subsets in humans: Vδ1, Vδ2 and Vδ3 T cells. The most abundant of these, Vδ2 T cells, ... -
Hepatic haematopoietic stem cells and the T Cell development potential of the adult human liver
(Trinity College (Dublin, Ireland). Department of Immunology, 2002)Large populations of innate T cells are found in the normal adult human liver (AHL), some of which may differentiate locally. The AHL also contains populations of functional myeloid and erythroid progenitors. The co-expression ... -
Identification of Schistosoma mansoni adult male worm excretome-secretome and production of recombinant proteins with immunomodulatory potential
(Trinity College (Dublin, Ireland). Department of Immunology, 2012)Over two billion people worldwide are infected with helminth parasites. Helminths strongly modulate the host’s immune response in order to establish a balanced parasite- host dynamic. This helminth-derived immunomodulatory ... -
Immune responses to tissue transglutaminase in coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2013)Coeliac disease is a common inflammatory disease of the small intestine caused by an inappropriate immune response to wheat gluten and gliadin in genetically predisposed individuals. Investigation into the pathogenesis of ... -
Immune variation in idiopathic bronchiectasis
(Trinity College (Dublin, Ireland). Department of Immunology, 2013)Bronchiectasis is a chronic suppurative lung disease. It is the pathological end-point of many disease processes including cystic fibrosis and antibody deficiency. In many cases of bronchiectasis, termed 'idiopathic', no ... -
In vivo and ex vivo examination of the safety of oats in coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2015)Coeliac disease is a chronic autoimmune disorder of the small intestine characterised by infiltration of intraepithelial lymphocytes, crypt hyperplasia and villous atrophy. It develops in genetically susceptible individuals ... -
Innate immunity and coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2008)Coeliac disease is a gluten sensitive enteropathy in which well defined gliadin peptides initiate a T cell mediated inflammatory response within the small intestine. This disseminates into destruction of the villous ... -
Investigating the impact of ABO blood group status on immune activity using data from the Milieu Intérieurcohort
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2024)The ABO blood group system is an important clinical determinant in transfusion medicine for the prevention of haemolytic transfusion reactions, and it has been linked to differential susceptibility to non-communicable ... -
Investigating the phenotype and functional roles of human liver-resident natural killer (NK) cells
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2021)The human liver is an immunologically complex organ populated with distinct resident immune cells including liver-resident CD56bright NK (lrNK) cells which have a distinct CD69+CXCR6+T-betloEomeshi phenotype. These ... -
Investigation of the Molluscum Contagiosum Virus Protein MC089 as a Novel Inhibitor of Interferon Regulatory Factor 3 Activation
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2024)Molluscum contagiosum virus (MCV) is a human-specific poxvirus that causes highly common, mild, papular skin lesions. The lesions are notable for exerting minimal to no inflammation but can persist for a long duration ... -
Investigation of the phenotypes, functions and therapeutic potential of expanded human invariant natural killer T cell subsets
(Trinity College (Dublin, Ireland). Department of Immunology, 2013)Invariant natural killer T (iNKT) cells comprise a rare subset of T cells that recognise glycolipid antigens presented by CDld. Activation of iNKT cells in mice leads to protection against cancer, autoimmune disease and ...