Collections in this Academic/Research Unit

Recent Submissions

  • Investigating the phenotype and functional roles of human liver-resident natural killer (NK) cells 

    Jameson, Grainne (Trinity College Dublin. School of Medicine. Discipline of Immunology, 2021)
    The human liver is an immunologically complex organ populated with distinct resident immune cells including liver-resident CD56bright NK (lrNK) cells which have a distinct CD69+CXCR6+T-betloEomeshi phenotype. These ...
  • Understanding the Role of IL-36 Family Cytokines in Paediatric IBD 

    Leon, Gemma (Trinity College Dublin. School of Medicine. Discipline of Immunology, 2021)
    Despite significant therapeutic advances, the global incidence of Inflammatory Bowel Diseases (IBD) continues to rise, with approximately 25% of these cases reported in childhood and adolescence. Aberrant CD4+ TΗ cell ...
  • The role of innate lymphocyte metabolism in sepsis 

    ALHARBI, ALHANOUF IBRAHIM (Trinity College Dublin. School of Medicine. Discipline of Immunology, 2020)
    Sepsis is the result of a dysregulated systemic immune response to microbial infection that leads to organ failure and death in about 30% of affected individuals. The antimicrobial response is biphasic with an overwhelming ...
  • The role and treatment potential of natural killer T (NKT) cells in patients with upper gastrointestinal cancers 

    MELO RODRIGUEZ, ASHANTY MAGGVIE (Trinity College Dublin. School of Medicine. Discipline of Immunology, 2019)
    Oesophageal adenocarcinoma (OAC), squamous cell carcinoma (SSC) and gastric cancers (GAC), collectively cause over 1.3 million deaths worldwide reported in 2018. Current therapeutic regimens focus on chemo-radiotherapy ...
  • Altered endotoxin responsiveness in healthy children with Down syndrome. 

    Roche, Edna; Doherty, Derek; Leahy, Ronan; Molloy, Eleanor; Balfe, Joanne (2018)
    Background: Down syndrome (DS) is the most common syndromic immunodeficiency with an increased risk of infection, mortality from sepsis, and autoinflammation. Innate immune function is altered in DS and therefore we examined ...

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