Design, optimisation and functional relevance of in silico tools for the study of coeliac disease
Citation:
Cathal O'Brien, 'Design, optimisation and functional relevance of in silico tools for the study of coeliac disease', [thesis], Trinity College (Dublin, Ireland). Department of Immunology, 2008, pp 213Download Item:
OBrien TCD THESIS 8402 Design optimisation.pdf (PDF) 124.7Mb
Abstract:
Peptide-MHC interaction is a crucial pre-requisite for the recognition of antigen by T cells. It has long been recognised that peptides with a high affinity for MHC molecules are more likely to elicit a pronounced T cell response. In order to reduce the experimental burden in studies of immunogenic protein fragments, many researchers have developed methods to predict the affinity of a peptide for a chosen MHC molecule. It was elected to develop such methods for the prediction of peptide binding to the coeliac disease associated MHC class II molecule HLA- DQ2.
Author: O'Brien, Cathal
Advisor:
Feighery, ConlethQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of ImmunologyNote:
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Full text availableKeywords:
Immunology, Ph.D., Ph.D. Trinity College DublinLicences: