Immunology (Theses and Dissertations)
Recent Submissions
-
Investigation of the Molluscum Contagiosum Virus Protein MC089 as a Novel Inhibitor of Interferon Regulatory Factor 3 Activation
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2024)Molluscum contagiosum virus (MCV) is a human-specific poxvirus that causes highly common, mild, papular skin lesions. The lesions are notable for exerting minimal to no inflammation but can persist for a long duration ... -
Investigating the impact of ABO blood group status on immune activity using data from the Milieu Intérieurcohort
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2024)The ABO blood group system is an important clinical determinant in transfusion medicine for the prevention of haemolytic transfusion reactions, and it has been linked to differential susceptibility to non-communicable ... -
Examining the role of lymphocytes in health and in neonatal encephalopathy and the influence of mucosal associated T cells on B cell functions
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2022)Background. Neonatal encephalopathy (NE) is a neurological syndrome in term babies characterised by altered levels of consciousness, seizures, abnormal tone and reflexes, and/or failure to initiate or maintain respiration. ... -
Investigating the phenotype and functional roles of human liver-resident natural killer (NK) cells
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2021)The human liver is an immunologically complex organ populated with distinct resident immune cells including liver-resident CD56bright NK (lrNK) cells which have a distinct CD69+CXCR6+T-betloEomeshi phenotype. These ... -
Understanding the Role of IL-36 Family Cytokines in Paediatric IBD
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2021)Despite significant therapeutic advances, the global incidence of Inflammatory Bowel Diseases (IBD) continues to rise, with approximately 25% of these cases reported in childhood and adolescence. Aberrant CD4+ TΗ cell ... -
The role of innate lymphocyte metabolism in sepsis
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2020)Sepsis is the result of a dysregulated systemic immune response to microbial infection that leads to organ failure and death in about 30% of affected individuals. The antimicrobial response is biphasic with an overwhelming ... -
The role and treatment potential of natural killer T (NKT) cells in patients with upper gastrointestinal cancers
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2019)Oesophageal adenocarcinoma (OAC), squamous cell carcinoma (SSC) and gastric cancers (GAC), collectively cause over 1.3 million deaths worldwide reported in 2018. Current therapeutic regimens focus on chemo-radiotherapy ... -
Effect of nutritional status and nutritional supplementation on clinical, nutritional and immunological outcomes among HIV infected adults in Uganda
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2019) -
The role of nutrition as a determinant of clinical, immunological and pharmacological outcome in HIV-infected children in Uganda
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2019)Introduction: Perinatally acquired HIV infection and malnutrition remain major public health challenges for sub-Saharan Africa health systems. HIV and malnutrition result in 50% mortality. The introduction of antiretroviral ... -
Defiency of natural killer receptor expressing cells in haemophagocytic lymphohistiocytosis
(Trinity College (Dublin, Ireland). Department of Immunology, 2002)Two children, patient A and patient B, were diagnosed on clinical and histological grounds to have haemophagocytic lymphohistiocytosis (HLH) (Henter et al. 1991a; Arico et al. 2001a). Clinical presentation of HLH consists ... -
Functional studies on human γδ T cells and their interactions with dendritic cells and B cells
(Trinity College (Dublin, Ireland). Department of Immunology, 2016)γδ T cells are innate T cells that play central roles in protection against microorganisms and cellular stress. There are three main subsets in humans: Vδ1, Vδ2 and Vδ3 T cells. The most abundant of these, Vδ2 T cells, ... -
Epigenetic targeting of CD1d increases cytolytic activity of invariant natural killer T cells against non-small cell lung cancer cells
(Trinity College (Dublin, Ireland). Department of Immunology, 2016)Lung cancer is the most common form of cancer-related death in the world, accounting for approximately 19.4% of all cancer mortalities. Currently platinum-based therapies are the gold-standard of care for non-small cell ... -
The impact of centrally and systemically administered TNFa on CNS inflamation and function
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Inflammation has long been recognised as a driver of dementia. However, the pathways by which inflammation alters neuronal function and causes neuronal death remain under investigation. Microglia are primed by chronic ... -
In vivo and ex vivo examination of the safety of oats in coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2015)Coeliac disease is a chronic autoimmune disorder of the small intestine characterised by infiltration of intraepithelial lymphocytes, crypt hyperplasia and villous atrophy. It develops in genetically susceptible individuals ... -
Regulation of B cell function by human invariant natural killer T cells in health and autoimmune disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2011)Invariant natural killer T (iNKT) cells are a subset of innate T lymphocytes that express a semi-invariant T cell receptor that recognises glycolipids presented on CD1d by antigen- presenting cells. They have the unique ... -
Characterisation of mouse strains with spontaneous mutations, leading to epidermal barrier dysfunction and inflammation
(Trinity College (Dublin, Ireland). Department of Immunology, 2013)Atopic dermatitis is a chronic pruritic skin disease, associated with eczematous lesions, epidermal barrier dysfunction, and Immunoglobulin-E-mediated sensitization to food and environmental allergens. The complex ... -
Investigation of the phenotypes, functions and therapeutic potential of expanded human invariant natural killer T cell subsets
(Trinity College (Dublin, Ireland). Department of Immunology, 2013)Invariant natural killer T (iNKT) cells comprise a rare subset of T cells that recognise glycolipid antigens presented by CDld. Activation of iNKT cells in mice leads to protection against cancer, autoimmune disease and ... -
Identification of Schistosoma mansoni adult male worm excretome-secretome and production of recombinant proteins with immunomodulatory potential
(Trinity College (Dublin, Ireland). Department of Immunology, 2012)Over two billion people worldwide are infected with helminth parasites. Helminths strongly modulate the host’s immune response in order to establish a balanced parasite- host dynamic. This helminth-derived immunomodulatory ... -
Immune variation in idiopathic bronchiectasis
(Trinity College (Dublin, Ireland). Department of Immunology, 2013)Bronchiectasis is a chronic suppurative lung disease. It is the pathological end-point of many disease processes including cystic fibrosis and antibody deficiency. In many cases of bronchiectasis, termed 'idiopathic', no ... -
Immune responses to tissue transglutaminase in coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2013)Coeliac disease is a common inflammatory disease of the small intestine caused by an inappropriate immune response to wheat gluten and gliadin in genetically predisposed individuals. Investigation into the pathogenesis of ...