Browsing Immunology (Theses and Dissertations) by Date of Publication
Now showing items 1-20 of 28
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Defiency of natural killer receptor expressing cells in haemophagocytic lymphohistiocytosis
(Trinity College (Dublin, Ireland). Department of Immunology, 2002)Two children, patient A and patient B, were diagnosed on clinical and histological grounds to have haemophagocytic lymphohistiocytosis (HLH) (Henter et al. 1991a; Arico et al. 2001a). Clinical presentation of HLH consists ... -
Hepatic haematopoietic stem cells and the T Cell development potential of the adult human liver
(Trinity College (Dublin, Ireland). Department of Immunology, 2002)Large populations of innate T cells are found in the normal adult human liver (AHL), some of which may differentiate locally. The AHL also contains populations of functional myeloid and erythroid progenitors. The co-expression ... -
Analysis of the autoantibody response directed against tissue transglutaminase in coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2006)Coeliac disease is an inflammatory disease of the proximal small intestine caused by wheat gluten ingestion in genetically susceptible individuals. The mucosal pathology in coeliac disease is characterised by villous ... -
Molecular events following gluten stimulation in coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2006)Coeliac disease is a common autoimmune disorder, caused by an intolerance to dietary gluten in genetically predisposed individuals. Despite the advances in understanding of the nature of the disease, it remains unknown how ... -
Characterisation of gut mucosa in patients with potential coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2007)Coeliac disease is a gluten dependent enteropathy with a high incidence and increased risk of mortality. Diagnosis of coeliac disease is based on a biopsy of small intestine. However, it is now believed that many individuals ... -
Innate immunity and coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2008)Coeliac disease is a gluten sensitive enteropathy in which well defined gliadin peptides initiate a T cell mediated inflammatory response within the small intestine. This disseminates into destruction of the villous ... -
Design, optimisation and functional relevance of in silico tools for the study of coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2008)Peptide-MHC interaction is a crucial pre-requisite for the recognition of antigen by T cells. It has long been recognised that peptides with a high affinity for MHC molecules are more likely to elicit a pronounced T cell ... -
Regulation of B cell function by human invariant natural killer T cells in health and autoimmune disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2011)Invariant natural killer T (iNKT) cells are a subset of innate T lymphocytes that express a semi-invariant T cell receptor that recognises glycolipids presented on CD1d by antigen- presenting cells. They have the unique ... -
Identification of Schistosoma mansoni adult male worm excretome-secretome and production of recombinant proteins with immunomodulatory potential
(Trinity College (Dublin, Ireland). Department of Immunology, 2012)Over two billion people worldwide are infected with helminth parasites. Helminths strongly modulate the host’s immune response in order to establish a balanced parasite- host dynamic. This helminth-derived immunomodulatory ... -
Evolutionary origins and functions of Schistosoma mansoni Pellino
(Trinity College (Dublin, Ireland). Department of Immunology, 2012)The immune system of modern man has innate signalling pathways that arose in ancestral species. This is exemplified by the discovery of the Toll-like receptor (TLR) pathway using free-living model organisms, specifically ... -
Characterisation of mouse strains with spontaneous mutations, leading to epidermal barrier dysfunction and inflammation
(Trinity College (Dublin, Ireland). Department of Immunology, 2013)Atopic dermatitis is a chronic pruritic skin disease, associated with eczematous lesions, epidermal barrier dysfunction, and Immunoglobulin-E-mediated sensitization to food and environmental allergens. The complex ... -
Investigation of the phenotypes, functions and therapeutic potential of expanded human invariant natural killer T cell subsets
(Trinity College (Dublin, Ireland). Department of Immunology, 2013)Invariant natural killer T (iNKT) cells comprise a rare subset of T cells that recognise glycolipid antigens presented by CDld. Activation of iNKT cells in mice leads to protection against cancer, autoimmune disease and ... -
Immune variation in idiopathic bronchiectasis
(Trinity College (Dublin, Ireland). Department of Immunology, 2013)Bronchiectasis is a chronic suppurative lung disease. It is the pathological end-point of many disease processes including cystic fibrosis and antibody deficiency. In many cases of bronchiectasis, termed 'idiopathic', no ... -
Immune responses to tissue transglutaminase in coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2013)Coeliac disease is a common inflammatory disease of the small intestine caused by an inappropriate immune response to wheat gluten and gliadin in genetically predisposed individuals. Investigation into the pathogenesis of ... -
The characterisation of peripheral blood and intestinal antigen presenting cells in coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2013)Antigen presenting cells, part of the innate immune system, play a central role in initiating and modulating the adaptive immune response. Coeliac disease is caused by aberrant activity of T cells specific for the dietary ... -
The impact of centrally and systemically administered TNFa on CNS inflamation and function
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Inflammation has long been recognised as a driver of dementia. However, the pathways by which inflammation alters neuronal function and causes neuronal death remain under investigation. Microglia are primed by chronic ... -
In vivo and ex vivo examination of the safety of oats in coeliac disease
(Trinity College (Dublin, Ireland). Department of Immunology, 2015)Coeliac disease is a chronic autoimmune disorder of the small intestine characterised by infiltration of intraepithelial lymphocytes, crypt hyperplasia and villous atrophy. It develops in genetically susceptible individuals ... -
Functional studies on human γδ T cells and their interactions with dendritic cells and B cells
(Trinity College (Dublin, Ireland). Department of Immunology, 2016)γδ T cells are innate T cells that play central roles in protection against microorganisms and cellular stress. There are three main subsets in humans: Vδ1, Vδ2 and Vδ3 T cells. The most abundant of these, Vδ2 T cells, ... -
Epigenetic targeting of CD1d increases cytolytic activity of invariant natural killer T cells against non-small cell lung cancer cells
(Trinity College (Dublin, Ireland). Department of Immunology, 2016)Lung cancer is the most common form of cancer-related death in the world, accounting for approximately 19.4% of all cancer mortalities. Currently platinum-based therapies are the gold-standard of care for non-small cell ... -
The role of nutrition as a determinant of clinical, immunological and pharmacological outcome in HIV-infected children in Uganda
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2019)Introduction: Perinatally acquired HIV infection and malnutrition remain major public health challenges for sub-Saharan Africa health systems. HIV and malnutrition result in 50% mortality. The introduction of antiretroviral ...