Show simple item record

dc.contributor.authorFinlay, David
dc.contributor.authorO'Brien, Katie L.
dc.date.accessioned2020-01-21T12:55:25Z
dc.date.available2020-01-21T12:55:25Z
dc.date.issued2019
dc.date.submitted2019en
dc.identifier.citationO'Brien, K.L. & Finlay, D.K., Immunometabolism and Natural Killer cell responses, Nature Reviews Immunology, 19, 5, 2019, 282 - 290en
dc.identifier.otherY
dc.identifier.urihttps://www.nature.com/articles/s41577-019-0139-2
dc.identifier.urihttp://hdl.handle.net/2262/91353
dc.descriptionPUBLISHEDen
dc.description.abstractNatural killer (NK) cells are lymphocytes with important roles in innate and adaptive immune responses to tumours and viral infection. However, in certain chronic diseases, including obesity and cancer, NK cell functional responses are impaired. Recently, research has highlighted the importance of NK cell metabolism in facilitating robust NK cell effector functions. This Review describes our current understanding of mouse and human NK cell metabolism and the key signalling pathways that mediate metabolic responses in NK cells. Furthermore, it explores how defects in metabolism can contribute to the generation of dysfunctional NK cells in chronic disease. Finally, the potential for new therapeutic strategies targeting cellular metabolism is discussed.en
dc.format.extent282en
dc.format.extent290en
dc.language.isoenen
dc.relation.ispartofseriesNature Reviews Immunology;
dc.relation.ispartofseries19;
dc.relation.ispartofseries5;
dc.rightsYen
dc.subjectNatural killer cellsen
dc.subjectLymphocyteen
dc.subjectImmune responseen
dc.subjectTumoursen
dc.subjectViral infectionen
dc.subjectImmune cell functionen
dc.subjectCellular metabolismen
dc.titleImmunometabolism and Natural Killer cell responsesen
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/finlayd
dc.identifier.rssinternalid193734
dc.identifier.doihttp://dx.doi.org/10.1038/s41577-019-0139-2
dc.rights.ecaccessrightsopenAccess
dc.contributor.sponsorGrantNumber13/CDA/2161en
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.subject.TCDTagImmunometabolismen
dc.subject.TCDTagNATURAL KILLER CELLSen
dc.identifier.orcid_id0000-0003-2716-6679
dc.status.accessibleNen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record