Investigation of the regulation of Bcl-2 family members in apoptosis and cancer
Citation:
Clare Sheridan, 'Investigation of the regulation of Bcl-2 family members in apoptosis and cancer', [thesis], Trinity College (Dublin, Ireland). Department of Genetics, 2010, pp 223Download Item:
Sheridan TCD THESIS 8947 Investigation of.pdf (PDF) 95.22Mb
Abstract:
Apoptosis is a highly controlled mechanism of cell suicide that is activated in
response to cellular stress and damage. The Bcl-2 family of proteins play a key
role in the regulation of this process. Opposing subsets of the Bcl-2 family either
promote or inhibit apoptosis, and interaction between rival family members
determines whether cell death will proceed. One subgroup, named the BH3-only
proteins, are activated in response to pro-apoptotic stimuli and promote the deathinducing function of the Bax-related subgroup. The third subgroup of this family
possess anti-apoptotic properties and antagonise the pro-apoptotic members of
the Bcl-2 family through sequestration of these proteins.
Author: Sheridan, Clare
Advisor:
SeamusQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of GeneticsNote:
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Genetics, Ph.D., Ph.D. Trinity College Dublin.Licences: