Regulation of innate and adaptive immunity by the vaccine adjuvant alum
Citation:
Ewa Oleszycka, 'Regulation of innate and adaptive immunity by the vaccine adjuvant alum', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013, pp 292Download Item:
Abstract:
While many licensed vaccines consist of whole or inactivated pathogens, there
is a move toward vaccines based on purified antigens which although safer are
generally less immunogenic and therefore require adjuvants to trigger protective
immunity. Alum, the most common adjuvant, has a record of successful use in
vaccines, where an antibody-mediated immune response can confer protective
immunity. However, alum is a poor inducer of cellular immune responses. The
mechanism underlying this selective enhancement of humoral responses is still not
well understood. Here, to gain an improved insight into its mode of action, innate
immune responses to alum and their impact on adaptive immune responses were
studied.
Author: Oleszycka, Ewa
Advisor:
Lavelle, EdQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Biochemistry and ImmunologyNote:
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