Investigation of the manipulation of phagocytes by Staphylococcus aureus
Citation:
Kate O'Keeffe, 'Investigation of the manipulation of phagocytes by Staphylococcus aureus', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015, pp 240Download Item:
Abstract:
The increasing prevalence of antibiotic resistance in Staphylococcus aureus
(S. aureus) heralds the advent of a "post-antibiotic era" that urgently
necessitates the development of novel treatment methods such as vaccines
and immunomodulatory therapies to provide an alternative to antibiotics. In
order to facilitate development in these therapeutic areas, a greater
understanding of the interactions between this bacterium and the host is
required. S. aureus' infective prowess stems from its vast capacity for immune
evasion. In recent years, it has been established that this bacteria is even
capable of survival within phagocytes, the archetypal killing cells of the
immune system. It has been proposed that this ability of S. aureus to survive
within phagocytes is likely a critical factor facilitating dissemination. This
thesis proposes that S. aureus survives inside phagocytes by subversion of
autophagy and manipulates apoptosis to prolong the availability of this niche.
Author: O'Keeffe, Kate
Advisor:
McLoughlin, Rachel M.Qualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Biochemistry and ImmunologyNote:
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