Chitosan based adjuvants promote proinflammatory Th1 and Th17 responses
Citation:
Andres Mori, 'Chitosan based adjuvants promote proinflammatory Th1 and Th17 responses', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012, pp 235Download Item:
Abstract:
Particulate vaccine adjuvants, including alum and biodegradable polymer microparticles,
are strong activators of antigen-specific humoral immunity. These particulates enhance
NLRP3 inflammasome activation, but they are limited in their ability to promote
proinflammatory T cells responses. For diseases such as TB and malaria, promotion of
strong Th1 responses is a prerequisite for effective vaccines but adjuvants that safely
promote such responses with subunit vaccines are lacking.
Author: Mori, Andres
Advisor:
Lavelle, EdQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Biochemistry and ImmunologyNote:
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