Exploration of RNAi-based theraupeutic strategies for Dominant Dystrophic Epidermolysis Bullosa
Citation:
Clare Morgan, 'Exploration of RNAi-based theraupeutic strategies for Dominant Dystrophic Epidermolysis Bullosa', [thesis], Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2011, pp 297Download Item:
Abstract:
The main focus of this Ph.D. thesis centres on exploration of a potential gene therapy for
treatment of the dystrophic form of the rare blistering skin disorder Epidermolysis Bullosa
(EB). There are three main subtypes of the disease, characterised by mutations of different
genes important for maintaining the integrity of epithelial lined or surfaced tissue layers of the
human body, but all of which result in a phenotype of fragility of the skin and mucous
membranes (Solovan et al, 2005; Fine, 2010a). All three forms of the disease are genetically
heterogeneous and symptoms range in severity according to the mutation in question.
Author: Morgan, Clare
Advisor:
Farrar, JaneQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Genetics and MicrobiologyNote:
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Full text availableKeywords:
Genetics, Ph.D., Ph.D. Trinity College Dublin.Metadata
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