The interaction of clumping factor B and iron regulated surface determinants of Staphylococcus aureus with platelets
Citation:
Helen Miajlovic, 'The interaction of clumping factor B and iron regulated surface determinants of Staphylococcus aureus with platelets', [thesis], Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2009, pp 270Download Item:
Abstract:
Clumping factor B (ClfB) of Staphylococcus aureus is a multi-functional surface
protein which binds to cytokeratin 10 and fibrinogen. Cytokeratin 10 is found on the
surface of desquamated epithelial cells of the anterior nares where it provides a ligand
for S. aureus cells expressing ClfB. ClfB contributes to nasal colonisation by S. aureus,
which is a risk factor for infection. S. aureus surface proteins that bind to the blood
glycoprotein fibrinogen can stimulate platelet aggregation by a fibrinogen-dependent
process. Aggregation of platelets by bacteria is believed to contribute to the
development of infective endocarditis of which S. aureus is now acknowledged to be
the leading cause.
Author: Miajlovic, Helen
Advisor:
Foster, TimQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Genetics and MicrobiologyNote:
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Full text availableKeywords:
Microbiology, Ph.D., Ph.D. Trinity College Dublin.Metadata
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