From single nucleotide polymorphisms to high-throughput sequencing in the complex genetics of amyotrophic lateral sclerosis
Citation:
Russell Lewis McLaughlin, 'From single nucleotide polymorphisms to high-throughput sequencing in the complex genetics of amyotrophic lateral sclerosis', [thesis], Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2012, pp 229Download Item:
Abstract:
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
progressive weakening of limb and bulbar muscles resulting in paralysis and death from
respiratory failure within three to five years of symptom onset. The disease manifests
as a consequence of sudden and rapid degeneration of upper and lower motor neurones,
for which the causative biomolecular processes are still relatively unknown.
Author: McLaughlin, Russell Lewis
Advisor:
Bradley, DanQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Genetics and MicrobiologyNote:
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