The identification and functional characterisation of caspase substrates involved in inflammation
Citation:
Alexander U. Luthi, 'The identification and functional characterisation of caspase substrates involved in inflammation', [thesis], Trinity College (Dublin, Ireland). Department of Genetics, 2010, pp 222Download Item:
Luthi TCD THESIS 9354 The identification.pdf (PDF) 89.38Mb
Abstract:
During inflammation the immune system responds to harmful stimuli, tries to
control the stimuli and initiate a healing process for damaged tissue. After
recognition of microbes by the innate immune system caspases are activated and
are required to activate cytokines. Human caspases have been studied for over
two decades with most work in the field focused on apoptotic caspases. As a
result hundreds of apoptotic caspase substrates have been identified to date, but
only 2 inflammatory caspase substrates have been confirmed. Identification of
novel targets for the caspases activated during the inflammatory process could
provide new insights into the molecular mechanism of host defense, identify
important immuno-regulatory molecules and targets for anti-inflammatory drug
development.
Author: Luthi, Alexander U.
Advisor:
Martin, SeamusQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of GeneticsNote:
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Genetics, Ph.D., Ph.D. Trinity College Dublin.Licences: