Exploring the role of granzymes in the induction of apoptosis
Citation:
Sean P. Cullen, 'Exploring the role of granzymes in the induction of apoptosis', [thesis], Trinity College (Dublin, Ireland). Department of Genetics, 2009, pp 216Download Item:
Abstract:
Cytotoxic Lymphocytes (CTL) and Natural Killer (NK) cells provide the body
with a powerful defence against viral infection, intracellular pathogens and
tumor development. After identifying an infected or damaged cell, CTL/NK
cells kill their targets by two main pathways involving either the ligation of death
receptors or the granule exocytosis pathway. In the granule pathway, CTL/NK
cells transfer a battery of death proteases called granzymes to the target cell
cytoplasm.
Author: Cullen, Sean P.
Advisor:
Martin, SeamusQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of GeneticsNote:
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Full text availableKeywords:
Genetics, Ph.D., Ph.D. Trinity College Dublin.Metadata
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