Genetic mechanisms establishing thalamocortical connectivity : novel genes and a role for Semaphorin6B
Citation:
Olivia Bahena-Bibollet, 'Genetic mechanisms establishing thalamocortical connectivity : novel genes and a role for Semaphorin6B', [thesis], Trinity College (Dublin, Ireland). Department of Genetics, 2015, pp 207Download Item:
Abstract:
One of the main functions of the brain is to process information from the
environment. All input to the neocortex passes through the thalamus in order to be
handled. Therefore, proper connectivity between the thalamus and the neocortex is
crucial. During brain development a staggeringly complex network of connections selfassembles
between billions of neurons through a finely orchestrated series of stages.
Extracellular proteins, known as guidance molecules, induce attractive or repulsive
responses from extending axons leading them through their journeys towards their
appropriate targets. Although different guidance molecules have been identified to date,
it is speculated that many more are required to explain the observed complexity in brain
connectivity.
Author: Bahena-Bibollet, Olivia
Advisor:
Mitchell, KevinQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of GeneticsNote:
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