Identification and characterisation of serotonin transporter interacting proteins
Citation:
Heidi Kaastrup Müller, 'Identification and characterisation of serotonin transporter interacting proteins', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2007, pp 248Download Item:
Muller TCD THESIS 8582 Identification and.pdf (PDF) 125.6Mb
Abstract:
The serotonin transporter (SERT) is an integral plasma membrane protein that
mediates the high-affinity re-uptake of the neurotransmitter serotonin from the
synaptic space. SERT is of particular clinical and phannacological interest as it has
been implicated in a variety of neuropsychiatric disorders as well as several
dysfunctions in the periphery. It is the primary target for a number of widely
prescribed antidepressants and is also the site of action for drugs of abuse. By
regulating the concentration of serotonin in extracellular fluids SERT plays a key
role in modulating serotonergic neurotransmission. The control of SERT activity via
intrinsic and trafficking mediated events is therefore central to the spatial and
temporal regulation of synaptic serotonin levels. SERT and related transporters are
thought to be regulated through association with a number of signalling and
structural proteins.
Author: Müller, Heidi Kaastrup
Advisor:
Haase, JanaQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Biochemistry and ImmunologyNote:
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Biochemistry, Ph.D., Ph.D. Trinity College DublinLicences: